943974-47-8

Basic information

• Product Name: 2-benzyl-5-bromo-1H-indole
• Synonyms: 2-benzyl-5-bromo-1H-indole
• CAS NO: 943974-47-8
• Molecular Weight: 286.171
• Mol File: 943974-47-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-benzyl-5-bromo-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-5-bromo-1H-indole(943974-47-8)
• EPA Substance Registry System: 2-benzyl-5-bromo-1H-indole(943974-47-8)

Safety Data

• Hazardous Substances Data: 943974-47-8(Hazardous Substances Data)

Upstream product

• 10075-51-1 1-benzyl-5-bromo-1H-indole 
• 10075-50-0 5-bromo-1H-indole 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Nickel-Catalyzed C(sp2)-H/C(sp3)-H Oxidative Coupling of Indoles with Toluene Derivatives

Nickel-catalyzed oxidative C(sp2)-H/C(sp3)-H coupling of indoles with toluene derivatives is successfully achieved in the presence of 2-iodobutane as the oxidant. This method allows the selective C-2 benzylation of indoles with toluene derivatives over the alkylation with 2-iodobutane and permits the coupling of diversified indoles via the monochelation assistance. The reaction proceeded through a single-electron-transfer (SET) process, wherein both the C-H nickelation of indole and the C-H activation of toluene derivatives have a significant effect on the entire reaction rate. The synthetic utility of this nickel-catalyzed protocol is demonstrated by the facile removal of the directing group and by the convenient synthesis of the melatonin receptor antagonist Luzindole derivatives.

PROTEIN KINASE INHIBITORS

Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.