943975-08-4

Upstream product

• 945652-57-3 di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(piperonyl)phosphonate 
• 25054-53-9 3,4-(methylenedioxy)benzoyl chloride 
• 211183-18-5 hydrogen di[(1R,2S,5R)-menthyl] phosphite 
• 120-57-0 piperonal 

Downstream Products

• 945652-57-3 di-[(1R,2S,5R)-(-)-menth-2-yl] hydroxy-(piperonyl)phosphonate 

Relevant academic research and scientific papers

Efficient method for the asymmetric reduction of α- and β-ketophosphonates

An efficient and versatile method for the asymmetric reduction of α- and β-ketophosphonates using chiral reactant derived from sodium borohydride and l-(+)- or d-(-)-tartaric acid is developed. The methodology was used for the preparation of a number of biologically interesting enantiomerically pure products: including 2,3-epoxypropylphosphonate 11, 2-hydroxy-3-aminopropylphosphonic acid 14 (phospho-GABOB), phospho-carnitine 19, and others in multigram scale.

Enantioselective reduction of ketophosphonates using chiral acid adducts with sodium borohydride

A method for asymmetric reduction of α-and β-ketophosphonates using a chiral complex prepared from sodium borohydride and D-or L-tartaric acid is developed. Reduction of α-or β-ketophosphonates by these reagents led to formation of corresponding (S)-or (R