945652-57-3Relevant academic research and scientific papers
Efficient method for the asymmetric reduction of α- and β-ketophosphonates
Nesterov,Kolodiazhnyi
, p. 6720 - 6731 (2008/02/07)
An efficient and versatile method for the asymmetric reduction of α- and β-ketophosphonates using chiral reactant derived from sodium borohydride and l-(+)- or d-(-)-tartaric acid is developed. The methodology was used for the preparation of a number of biologically interesting enantiomerically pure products: including 2,3-epoxypropylphosphonate 11, 2-hydroxy-3-aminopropylphosphonic acid 14 (phospho-GABOB), phospho-carnitine 19, and others in multigram scale.
Enantioselective reduction of ketophosphonates using chiral acid adducts with sodium borohydride
Nesterov,Kolodyazhnyi
, p. 1022 - 1030 (2008/02/05)
A method for asymmetric reduction of α-and β-ketophosphonates using a chiral complex prepared from sodium borohydride and D-or L-tartaric acid is developed. Reduction of α-or β-ketophosphonates by these reagents led to formation of corresponding (S)-or (R
