943980-75-4Relevant articles and documents
Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor
Chen, Liqiang,Gao, Guangyao,Bonnac, Laurent,Wilson, Daniel J.,Bennett, Eric M.,Jayaram, Hiremagalur N.,Pankiewicz, Krzysztof W.
, p. 3152 - 3155 (2007)
A methylenebis(sulfonamide) linked NAD analogue has been designed to circumvent the metabolically unstable, ionic nature of the natural pyrophosphate linkage. This NAD analogue is assembled through two Mitsunobu reactions of a methylenebis(sulfonamide) li
Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: Inhibition of inosine monophosphate dehydrogenase
Chen, Liqiang,Petrelli, Riccardo,Olesiak, Magdalena,Wilson, Daniel J.,Labello, Nicholas P.,Pankiewicz, Krzysztof W.
, p. 7462 - 7469 (2008/12/23)
Synthesis of novel inhibitors of human IMP dehydrogenase is described. These inhibitors are isosteric methylenebis(sulfonamide) analogues 5-8 of earlier reported mycophenolic adenine methylenebis(phosphonate)s 1-3. The parent bis(phosphonate) 1 and its bi