944030-48-2Relevant articles and documents
(S)-4/5-phenyl-2-(pyrrolidin-2-yl)thiazole TRPV1 antagonists as well as preparation and application thereof
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Paragraph 0050; 0124; 0130-0131, (2020/07/28)
The invention discloses (S)-4/5-phenyl-2-(pyrrolidin-2-yl)thiazole novel TRPV1 antagonists as well as a preparation method and application thereof, and particularly relates to compounds represented bya general formula (I) or a general formula (II) and a pharmaceutically acceptable salt thereof. The compound have a strong analgesic effect, the activity of part of the compounds is far higher than that of a TRPV1 receptor antagonist BCTC, almost no body temperature rise side effect exists, and the invention further relates to a preparation method of the compounds and pharmaceutical preparationscontaining the compounds.
Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres
Cohen, Frederick,Koehler, Michael F.T.,Bergeron, Philippe,Elliott, Linda O.,Flygare, John A.,Franklin, Matthew C.,Gazzard, Lewis,Keteltas, Stephen F.,Lau, Kevin,Ly, Cuong Q.,Tsui, Vickie,Fairbrother, Wayne J.
scheme or table, p. 2229 - 2233 (2010/06/15)
A series of IAP antagonists based on thiazole or benzothiazole amide isosteres was designed and synthesized. These compounds were tested for binding to the XIAP-BIR3 and ML-IAP BIR using a fluorescence polarization assay. The most potent of these compound
