944109-65-3

Basic information

• Product Name: 4-CHLORO-5-METHOXY-1-INDANONE
• Synonyms: 4-CHLORO-5-METHOXY-1-INDANONE;4-Chloro-5-Methoxy-2,3-dihydro-1H-inden-1-one;4-Chloro-5-methoxy-1-indanone 97%;4-Chloro-5-methoxy-indan-1-one
• CAS NO: 944109-65-3
• Molecular Formula: C10H9ClO2
• Molecular Weight: 196.63026
• Product Categories: C10;Carbonyl Compounds;Ketones
• Mol File: 944109-65-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 124-128 °C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-CHLORO-5-METHOXY-1-INDANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-METHOXY-1-INDANONE(944109-65-3)
• EPA Substance Registry System: 4-CHLORO-5-METHOXY-1-INDANONE(944109-65-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 944109-65-3(Hazardous Substances Data)

Usage

General Description

4-CHLORO-5-METHOXY-1-INDANONE is a chemical compound with the molecular formula C10H9ClO2. It is a white to light yellow solid that is primarily used as an intermediate in the production of pharmaceuticals and agrochemicals. 4-CHLORO-5-METHOXY-1-INDANONE is an important building block in the synthesis of various organic compounds due to its versatile reactivity and functional groups. It is commonly used in the preparation of indole derivatives, which are valuable in the pharmaceutical industry for their potential as drug candidates. Additionally, 4-CHLORO-5-METHOXY-1-INDANONE has applications in the synthesis of insecticides and herbicides due to its ability to modify the structure and activity of organic molecules.

Upstream product

• 5111-70-6 5-methoxy-1-indanone 

Relevant articles and documents

Development of a phase transfer catalyzed asymmetric synthesis for an estrogen receptor beta selective agonist

A practical asymmetric synthesis of the estrogen receptor beta selective agonist (7β-9aβ)-1,4-dichloro-2-hydroxjgibba-1(10a)2,4,4b-tetraen-6- one (1), proceeding by way of six isolated intermediates and without recourse to chromatography, is described. Highlights of the process route developed are two chemoselective chlorinations, a lithiated hydrazone alkylation and an asymmetric Michael addition of indanone 11 to methyl vinyl ketone (using 15 mol % of cinchonine-derived catalyst 20g) to set the all-carbon quaternary asymmetric stereocenter. The challenges addressed in scaling the latter heterogeneous biphasic phase transfer reaction to 44 mol (14 kg) scale are discussed in detail. Overall, the chemistry developed has been used to prepare > 6 kg of drug candidate 1 in 18% overall yield and with >99% ee.