944154-77-2Relevant academic research and scientific papers
PYRAZOLE CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND ITS PREPARATION
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Page/Page column 4, (2010/07/04)
A compound of formula (I) or pharmaceutically acceptable salts and/or solvates or hydrates thereof. A process for preparing the compound, a pharmaceutical composition comprising the compound and an application for resisting cannabinoid CB1 receptor are pr
Synthesis and cannabinoid activity of a variety of 2,3-substituted 1-benzo[b]thiophen derivatives and 2,3-substituted benzofuran: Novel agonists for the CB1 receptor
Moloney, Gerard P.,Angus, James A.,Robertson, Alan D.,Stoermer, Martin J.,Robinson, Michael,Lay, Lucy,Wright, Christine E.,McRae, Ken,Christopoulos, Arthur
, p. 484 - 499 (2008/12/20)
An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB1 agonists. It is hoped that compounds of this type will have clinical utility in pain control and cerebral ischaemia following stroke or traumatic head injury. We report here medicinal chemistry studies directed towards the investigation of several classes of 1-benzo[b]thiophen and benzofuran derivatives as novel CB1 agonists. We have discovered a novel series of compounds, which contain a 1-benzo[b]thiophen or a benzofuran group as the central aromatic group. Our investigation of this series of compounds has enhanced our understanding of the importance of binding sites within the CB1 receptor for favourable CB1 potency. Our understanding of these factors allowed us to modify the structure of a 1-benzothiophen derivative and improve its potency at the CB1 receptor. CSIRO 2008.
PYRAZOLE CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND ITS PREPARATION
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Page/Page column 3; 4; 6, (2008/12/07)
The present invention relates to a compound of formula (I) and pharmaceutically acceptable salts and/or solvates or hydrates thereof, a process for preparing the compound, a pharmaceutical composition comprising the compound and its use for resisting cann
