94416-66-7

Usage

Uses

Used in Organic Synthesis:
3,4-Dimethylbenzylbromide is used as a reagent for the synthesis of various organic compounds due to its high reactivity, facilitating the creation of pharmaceuticals, agrochemicals, and specialty chemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3,4-Dimethylbenzylbromide is employed as a key intermediate in the development of new drugs, leveraging its ability to participate in complex chemical reactions that are essential for medicinal chemistry.
It is crucial to handle 3,4-Dimethylbenzylbromide with care due to its toxic nature and potential to cause irritation to the skin, eyes, and respiratory system. Proper safety measures should be implemented during its use to mitigate any adverse effects.

Upstream product

• 6966-10-5 3,4-dimethylbenzyl alcohol 
• 5973-71-7 3,4-dimethylbenzaldehyde 
• 50-00-0 formaldehyd 
• 95-47-6 o-xylene 
• 619-04-5 3,4-dimethylbenzoic acid 

Downstream Products

• 617714-65-5 1-(3,4-dimethyl-benzyl)-piperidin-4-one 
• 1213310-14-5 N-Boc-(S)-3',4'-dimethylphenylalanine 
• 96293-17-3 (S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide 
• 401573-44-2 ethyl 3-(3,4-dimethylphenyl)-2-[(diphenylmethylene)amino]propanoate 
• 928776-01-6 4-(3,4-dimethyl-benzyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde 
• 617714-47-3 1-[1-(3,4-dimethyl-benzyl)-piperidin-4-yl]-3-methyl-butan-2-one 
• 617714-44-0 1-[1-(3,4-dimethyl-benzyl)-piperidin-4-yl]-3-methyl-butan-2-ol 
• 617714-49-5 1-[1-(3,4-dimethyl-benzyl)-piperidin-4-ylmethyl]-2-methyl-propylamine 
• 617714-39-3 [1-(3,4-dimethyl-benzyl)-piperidin-4-yl]-acetic acid ethyl ester 
• 617714-37-1 [1-(3,4-dimethyl-benzyl)-piperidin-4-ylidene]-acetic acid ethyl ester 

Relevant academic research and scientific papers

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Synthesis of 2,2-dimethyl-3-(3-methyl phenyl)propanal and its derivatives

An alternative approach to the synthesis of 2,2-dimethyl-3-(3-methylphenyl) propanal and its derivatives was described. 2,2-Dimethyl-3-(3-methylphenyl) propanal and its derivatives were obtained in middle yields from various substituted alkylaromtics, via bromination and alkylation. Its feature of fragrance was green, reminiscent of leaves, with flowery-aldehydic aspects. Copyright

Synthesis and in vitro antibacterial activity of gemifloxacin derivatives containing a substituted benzyloxime moiety

A series of novel gemifloxacin (GMFX) derivatives containing a substituted benzyloxime moiety with remarkable improvement in lipophilicity were synthesized. The target compounds evaluated for their in vitro antibacterial activity against representative strains. Our results reveal that most of the target compounds have considerable potency against all of the tested Gram-positive strains including MRSA and MRSE (MIC: 90: 1 μg/mL) is 8-fold more active than GMFX, and 2-fold more active than GMFX and moxifloxacin against MRSE clinical isolates (MIC90: 4 μg/mL). Crown Copyright

Paracyclophanes. Part 58 [1]. On the use of the stilbene-phenanthrene photocyclization in [2.2]paracyclophane chemistry

The application of the stilbene→phenanthrene photocyclization to [2.2]paracyclophane chemistry has been investigated. For the model system 4-styryl[2.2]paracyclophane (2) to [2.2]phenanthrenoparacyclophane (3) the reaction allows the introduction of alkyl substituants in the 6-, 7-, 8- and 9-position of the phenanthrene moiety. However, when the substituent in the 9-position (bay area of phenanthrene nucleus) becomes too large, viz. tert-butyl, no ring closure is observed anymore. The side products of the process (ring cleavage products of the cyclophane core such as 9 and 10) have been characterized for the first time. Extension of the condensed deck is possible leading to PAH-phanes as demonstrated by the preparation of the chrysenophanes 45 and 60; the cyclization to novel helicenophanes such as 50 also takes place without difficulties. In the case of 1,2-di(4-[2.2] paracyclophanyl)ethene (63) the triply-layered hydrocarbon 65 is produced on irradiation in small amounts.

An improved method for the regiospecific synthesis of polysubstituted [2.2]paracyclophanes

4,16-Disubstituted, 4,7,12,15-tetrasubstituted, 4,8,12,16-tetrasubstituted and 4,5,7,8,12,13,15,16-octasubstituted [2.2]paracyclophanes can be prepared in significantly improved yields and excellent regiospecificities via the Winberg 1,6-elimination-dimerization reaction from substituted (4-methylbenzyl) trimethylammonium hydroxides. Using 2-chloro-phenothiazine instead of phenothiazine as a polymerization inhibitor results in a doubling of product yields. Georg Thieme Verlag Stuttgart.

Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit?

A series of combretastatins possessing both a trimethoxy unit and other substituents on ring A has been synthesised and tested for cytotoxicity and their ability to interact with the protein tubulin. All previous studies have indicated that the trimethoxy

Binding activity of substituted benzyl derivatives of chloronicotinyl insecticides to housefly-head membranes, and its relationship to insecticidal activity against the housefly Musca domestica

Variously substituted benzyl derivatives of chloronlcotinyl insecticides were synthesized with a wide range of substituents including halogens, NO2, CN, CF3 and small alkyl and alkoxy groups at the ortho, meta and para positions, as well as multiple-substituted benzyl analogues. Their binding activity to the α-bungarotoxin binding site in housefly (Musca domestica) head membrane preparations was measured. Among the compounds tested, the activity of the meta-CN derivative was the highest, being 20-100 times higher than those of imidacloprid, acetamiprid and nitenpyram. The synergized insecticidal activity against houseflies was also measured for selected compounds with the metabolic inhibitor, NIA16388 (propargyl propyl phenylphosphonate). For the nitromethylene analogues, including both benzyl and pyridylmethyl analogues, higher binding activity usually resulted in higher insecticidal activity. (C) 2000 Society of Chemical Industry.

Regioselective bromomethylation of 1,2-dialkylbenzenes

This paper describes a systematic exploration of the regioselective bromomethylation of 1,2-dialkylbenzenes as a function of the reaction temperature and the chain length of the alkyl groups. At both 80 and 110 °C, bromomethyl groups can be introduced into the 4 and 5 positions of 1,2-dialkylbenzenes with high selectivity when the alkyl chains consist of two or more carbon atoms.

A NOVEL ONE STEP CONVERSION OF ALCOHOLS INTO ALKYL BROMIDES OR IODIDES

Alcohols are converted in high yields into alkyl bromides or iodides by a one step reaction with N,N'-carbonyldiimidazole and an excess of reactive halides such as allyl bromide or methyl iodide.KEYWORDS - alcohol; N,N'-carbonyldiimidazole; bromination; iodination; 1-alkoxycarbonylimidazole; 1-alkoxycarbonyl-3-substituted imidazolium salt; allyl bromide; methyl iodide