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5973-71-7

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5973-71-7 Usage

Chemical Properties

Clear colorless to yellowish liquid

Uses

3,4-Dimethylbenzaldehyde is used as an additive for resins, agricultural intermediate and for flavor and fragrance, nucleation transparent agent.

General Description

3,4-Dimethylbenzaldehyde (3,4-DMB) is a benzaldehyde derivative. It is the OH radical initiated oxidative degradation product of trimethylbenzene. The rate coefficient of the gas-phase reaction between 3,4-DMB and OH radical is 24.6±4.0×10-12cm3molecule-1s-1. The vibrational analysis of 3,4-DMB based on FT-IR spectra, FT-Raman spectra, ab initio and density functional theory (DFT) calculations have been reported. It is formed as an intermediate during the transformation of furfural into gasoline-range fuels using ZSM(Zeolite Socony Mobil)-5-based catalysts.

Flammability and Explosibility

Nonflammable

Check Digit Verification of cas no

The CAS Registry Mumber 5973-71-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,7 and 3 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5973-71:
(6*5)+(5*9)+(4*7)+(3*3)+(2*7)+(1*1)=127
127 % 10 = 7
So 5973-71-7 is a valid CAS Registry Number.

5973-71-7 Well-known Company Product Price

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  • (Code)Product description
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  • Detail
  • Alfa Aesar

  • (A15388)  3,4-Dimethylbenzaldehyde, 97%   

  • 5973-71-7

  • 5g

  • 957.0CNY

  • Detail
  • Alfa Aesar

  • (A15388)  3,4-Dimethylbenzaldehyde, 97%   

  • 5973-71-7

  • 25g

  • 4615.0CNY

  • Detail

5973-71-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,4-Dimethylbenzaldehyde

1.2 Other means of identification

Product number -
Other names 3,4-Me2C6H3CHO

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5973-71-7 SDS

5973-71-7Synthetic route

3,4‐dimethylbenzaldoxime

3,4‐dimethylbenzaldoxime

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

3,4-dimethylbenzyl alcohol
6966-10-5

3,4-dimethylbenzyl alcohol

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With ammonium hydroxide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In ethanol at 50℃; for 18h;96%
With ammonium hydroxide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(ll) bromide at 80℃; for 20h;96%
With Iron(III) nitrate nonahydrate; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,2-dichloro-ethane at 60℃; for 3h; Schlenk technique; Green chemistry;96%
4-(chloromethyl)-1,2-dimethylbenzene
102-46-5

4-(chloromethyl)-1,2-dimethylbenzene

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With sodium nitrate; acetic acid In water for 3h; Reflux;92%
With potassium hydroxide; cetyltrimethylammonim bromide; potassium nitrate In water for 6h; pH=10 - 11; Reflux;81%
(chloro)(3,4-dimethylphenyl)methyl p-tolyl sulfoxide

(chloro)(3,4-dimethylphenyl)methyl p-tolyl sulfoxide

A

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

B

di(p-tolyl) disulfide
103-19-5

di(p-tolyl) disulfide

C

3,5-di(3,4-dimethylphenyl)-1,2,4,6-thiatriazine 1-oxide
307929-13-1

3,5-di(3,4-dimethylphenyl)-1,2,4,6-thiatriazine 1-oxide

D

3,4-dimethylbenzonitrile
22884-95-3

3,4-dimethylbenzonitrile

Conditions
ConditionsYield
With tetrasulphure tetranitride In 1,4-dioxane for 7h; Heating;A n/a
B 86%
C 22%
D n/a
3,4-dimethylbenzyl bromide
94416-66-7

3,4-dimethylbenzyl bromide

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With potassium nitrite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In water for 5h; Reflux;85%
o-xylene
95-47-6

o-xylene

N,N,N',N'-tetraformylhydrazine
52023-52-6

N,N,N',N'-tetraformylhydrazine

A

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

B

3,4-Dimethylbenzaldehyd-azin

3,4-Dimethylbenzaldehyd-azin

Conditions
ConditionsYield
Stage #1: o-xylene; N,N,N',N'-tetraformylhydrazine With aluminium trichloride In 1,2-dichloro-ethane at -15 - 1℃; for 19h;
Stage #2: With water
A 9%
B 77%
carbon monoxide
201230-82-2

carbon monoxide

3,4-dimethyliodobenzene
31599-61-8

3,4-dimethyliodobenzene

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; formic acid; tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide at 60℃; under 760 Torr; Carbonylation; Electrochemical reaction;76%
o-xylene
95-47-6

o-xylene

tris(diformylamino)methane
332047-72-0

tris(diformylamino)methane

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
Stage #1: o-xylene; tris(diformylamino)methane With aluminium trichloride In 1,2-dichloro-ethane at -19 - 0℃;
Stage #2: With water Heating;
65%
With aluminium trichloride In 1,2-dichloro-ethane at -19 - -1℃; for 15h;42%
o-xylene
95-47-6

o-xylene

tris(diformylamino)methane
332047-72-0

tris(diformylamino)methane

A

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

B

3,3',4,4'-tetramethyl-1,2-diphenylethane
34101-86-5

3,3',4,4'-tetramethyl-1,2-diphenylethane

Conditions
ConditionsYield
With aluminium trichloride In 1,2-dichloro-ethane Product distribution; Further Variations:; reagent amount;A 64%
B 3%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

3,4-dimethylbenzyl alcohol
6966-10-5

3,4-dimethylbenzyl alcohol

Triphenylphosphine oxide
791-28-6

Triphenylphosphine oxide

A

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

B

Hexamethyldisiloxane
107-46-0

Hexamethyldisiloxane

C

triphenylphosphine
603-35-0

triphenylphosphine

Conditions
ConditionsYield
With 2,6-dimethylpyridine; tetrabutylammonium tetrafluoroborate In acetonitrile at 40℃; Electrochemical reaction;A 61%
B 10%
C 72 %Spectr.
3,4-dimethylstyrene
27831-13-6

3,4-dimethylstyrene

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With 1-hydroxy-pyrrolidine-2,5-dione; graphitic carbon nitride; oxygen In acetonitrile at 20℃; Inert atmosphere; Irradiation;60%
o-xylene
95-47-6

o-xylene

triformylamine
25891-31-0

triformylamine

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With aluminium trichloride In 1,2-dichloro-ethane at -30 - -4℃; for 12h; Formylation;43%
ethanol
64-17-5

ethanol

3,4-dimethylbenzyl alcohol
6966-10-5

3,4-dimethylbenzyl alcohol

A

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

B

3-(3,4-dimethylphenyl)-2-propylene aldehyde

3-(3,4-dimethylphenyl)-2-propylene aldehyde

C

5-(3,4-dimethyl-phenyl)-penta-2,4-dienal

5-(3,4-dimethyl-phenyl)-penta-2,4-dienal

Conditions
ConditionsYield
With oxygen; potassium carbonate In 1,4-dioxane at 60℃; for 48h;A 40%
B 20%
C 30%
o-xylene
95-47-6

o-xylene

bis(diformylamino)methane
877680-60-9

bis(diformylamino)methane

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With aluminum (III) chloride In chlorobenzene at -12 - 18℃; for 22h;37%
o-xylene
95-47-6

o-xylene

triformylamine
25891-31-0

triformylamine

A

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

B

N-[bis-(3,4-dimethyl-phenyl)-methyl]-formamide

N-[bis-(3,4-dimethyl-phenyl)-methyl]-formamide

Conditions
ConditionsYield
With aluminium trichloride In chlorobenzene at -15 - -6℃; for 16h; Product distribution; Further Variations:; Temperatures; Reagents; Solvents; ratio; addition sequence; Formylation; condensation;A 30%
B n/a
o-xylene
95-47-6

o-xylene

carbon monoxide
201230-82-2

carbon monoxide

A

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

B

5-formyl-2,3-dimethylbenzenesulfonyl fluoride
139689-26-2

5-formyl-2,3-dimethylbenzenesulfonyl fluoride

Conditions
ConditionsYield
With antimony pentafluoride; fluorosulphonic acid at 0℃; under 760 Torr; for 96h; Yield given;A 6%
B n/a
hydrogen cyanide
74-90-8

hydrogen cyanide

o-xylene
95-47-6

o-xylene

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With hydrogenchloride; aluminium trichloride Zersetzung des Reaktionsproduktes mit Eis und Salzsaeure;
o-xylene
95-47-6

o-xylene

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With aluminium trichloride; hydrogen cyanide at 100℃; Einleiten von HCl und anschliessend Behandeln mit Eis und wss. HCl;
Multi-step reaction with 2 steps
1: aluminium chloride
2: diluted alkali
View Scheme
Multi-step reaction with 3 steps
1: aluminium chloride
2: diluted alkali
View Scheme
1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With manganese(IV) oxide; sulfuric acid
With sulfuric acid In acetonitrile at 50 - 80℃; for 24h; Reagent/catalyst;
3,4-dimethyl-mandelic acid
5766-03-0

3,4-dimethyl-mandelic acid

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

β-chloro-3,4-dimethyl-styrene

β-chloro-3,4-dimethyl-styrene

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With permanganate(VII) ion; acetone
2,2,2-trichloro-1-(3,4-dimethyl-phenyl)-ethanol

2,2,2-trichloro-1-(3,4-dimethyl-phenyl)-ethanol

A

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

B

3,4-dimethyl-mandelic acid
5766-03-0

3,4-dimethyl-mandelic acid

Conditions
ConditionsYield
With diluted alkali
3,4-dimethyl-benzoic acid-(N-methyl-anilide)
349109-03-1

3,4-dimethyl-benzoic acid-(N-methyl-anilide)

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With tetrahydrofuran; lithium aluminium tetrahydride
3,4-dimethylphenylmagnesium bromide
89980-68-7

3,4-dimethylphenylmagnesium bromide

ethyl N-phenylformimidate
6780-49-0

ethyl N-phenylformimidate

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With diethyl ether anschliessend mit wss.HCl;
3,4-dimethylbenzoyl chloride
21900-23-2

3,4-dimethylbenzoyl chloride

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With Pd-BaSO4; xylene at 140 - 150℃; Hydrogenation;
chloroform
67-66-3

chloroform

3,4-dimethylbenzonitrile
22884-95-3

3,4-dimethylbenzonitrile

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With hydrogenchloride; diethyl ether; tin(ll) chloride Erwaermen des Reaktionsprodukts mit H2O;
methanol
67-56-1

methanol

4,4-dimethylcyclohexa-2,5-dienone
1073-14-9

4,4-dimethylcyclohexa-2,5-dienone

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
titanium tetrachloride Irradiation;
(3,4-Dimethyl-phenyl)-nitromethan
33241-78-0

(3,4-Dimethyl-phenyl)-nitromethan

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

Conditions
ConditionsYield
With potassium permanganate
o-xylene
95-47-6

o-xylene

carbon monoxide
201230-82-2

carbon monoxide

A

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

B

2,3-dimethylbenzaldehyde
5779-93-1

2,3-dimethylbenzaldehyde

Conditions
ConditionsYield
With antimony pentafluoride; fluorosulphonic acid at 0℃; under 760 Torr; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
(4R,5R)-1-C-(1,2-dimethyl-4-nitrocyclohex-1-en-5-yl)carbaldehyde
125488-63-3

(4R,5R)-1-C-(1,2-dimethyl-4-nitrocyclohex-1-en-5-yl)carbaldehyde

A

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

B

4,5-dimethylcyclohexa-1,4-diene-1-carbaldehyde
82372-64-3

4,5-dimethylcyclohexa-1,4-diene-1-carbaldehyde

Conditions
ConditionsYield
With potassium carbonate In methanol for 1h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

acetone
67-64-1

acetone

(E)-4-(3,4-dimethylphenyl)but-3-en-2-one
97241-86-6

(E)-4-(3,4-dimethylphenyl)but-3-en-2-one

Conditions
ConditionsYield
With sodium hydroxide In water at 0 - 25℃; for 6h;100%
With sodium hydroxide
With sodium hydroxide In water at 25℃; for 12h;
3-{[bis-(2-hydroxy-propyl)-amino]-methyl}-N-(3-hydrazinocarbonyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-benzamide
773071-20-8

3-{[bis-(2-hydroxy-propyl)-amino]-methyl}-N-(3-hydrazinocarbonyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-benzamide

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

3-{[bis-(2-hydroxy-propyl)-amino]-methyl}-N-[3-(3,4-dimethyl-benzylidene-hydrazinocarbonyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]-benzamide

3-{[bis-(2-hydroxy-propyl)-amino]-methyl}-N-[3-(3,4-dimethyl-benzylidene-hydrazinocarbonyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]-benzamide

Conditions
ConditionsYield
In toluene at 20℃; for 15h; Heating / reflux;100%
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

cis, trans-1,3-dimethylaminocyclohexane
2579-20-6

cis, trans-1,3-dimethylaminocyclohexane

C26H34N2
1217526-73-2

C26H34N2

Conditions
ConditionsYield
In methanol at 20℃; Molecular sieve;100%
In methanol at 20℃; Molecular sieve;
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

N-prenyl-N-propargyltosylamide
132330-44-0

N-prenyl-N-propargyltosylamide

C24H29NO3S
1363388-69-5

C24H29NO3S

Conditions
ConditionsYield
Stage #1: N-prenyl-N-propargyltosylamide With ethylmagnesium bromide In tetrahydrofuran at 50℃; for 1h;
Stage #2: 3,4-dimethylbenzaldehyde In tetrahydrofuran at 20℃; for 3h;
100%
Stage #1: N-prenyl-N-propargyltosylamide With ethylmagnesium bromide In tetrahydrofuran at 50℃; for 1h;
Stage #2: 3,4-dimethylbenzaldehyde In tetrahydrofuran at 20℃; for 3h;
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

(E)-ethyl 3-(3,4-dimethylphenyl)acrylate
81069-49-0, 83004-26-6

(E)-ethyl 3-(3,4-dimethylphenyl)acrylate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With lithium chloride In tetrahydrofuran at 20℃; for 0.25h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
Stage #2: 3,4-dimethylbenzaldehyde With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
100%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 30℃; for 4h; Glovebox;99%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: 3,4-dimethylbenzaldehyde In tetrahydrofuran
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

D-sorbitol
50-70-4

D-sorbitol

1,3:2,4-di-O-(3,4-dimethylbenzylidene)-D-sorbitol
135861-56-2

1,3:2,4-di-O-(3,4-dimethylbenzylidene)-D-sorbitol

Conditions
ConditionsYield
toluene-4-sulfonic acid In acetonitrile at 20℃; for 12h; Product distribution / selectivity;99%
With trimethyl orthoformate; bismuth(lll) trifluoromethanesulfonate In methanol at 20℃; for 48h; Product distribution / selectivity;99%
With trimethyl orthoformate; bismuth(lll) trifluoromethanesulfonate In methanol at 20℃; for 49h; Product distribution / selectivity; Heating / reflux;99%
tetrahydrofuran-2,4-dione
4971-56-6

tetrahydrofuran-2,4-dione

1-Phenyl-3-methyl-5-aminopyrazole
1131-18-6

1-Phenyl-3-methyl-5-aminopyrazole

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

4-(3,4-dimethylphenyl)-3-methyl-1-phenyl-1H-furo[3,4-e]pyrazolo[3,4-b]pyridine-5(7H)-one
1173933-03-3

4-(3,4-dimethylphenyl)-3-methyl-1-phenyl-1H-furo[3,4-e]pyrazolo[3,4-b]pyridine-5(7H)-one

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride In water at 90℃; for 10h;97%
With 1-n-butyl-3-methylimidazolim bromide at 95℃; for 2h;91%
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

phenylboronic acid
98-80-6

phenylboronic acid

phenyl 3,4-dimethylbenzoate

phenyl 3,4-dimethylbenzoate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3-bis(mesityl)imidazolium chloride In dimethyl sulfoxide at 80℃; for 0.5h;97%
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

A

o-xylene
95-47-6

o-xylene

B

1,2,4-Trimethylbenzene
95-63-6

1,2,4-Trimethylbenzene

Conditions
ConditionsYield
With palladium/alumina; hydrogen In hexane at 325℃; Flow reactor; Green chemistry;A 96.2%
B 3.8%
With hydrogen In hexane at 325℃; Flow reactor; Green chemistry;A 15.9%
B 84.2%
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

1,3-cylohexanedione
504-02-9

1,3-cylohexanedione

1-amino-5,5-dimethylcyclohexen-3-one
873-95-0

1-amino-5,5-dimethylcyclohexen-3-one

(+/-)-9-(3,4-dimethylphenyl)-3,3-dimethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione

(+/-)-9-(3,4-dimethylphenyl)-3,3-dimethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride In water at 100℃; for 6h;96%
N-(2-hydrazinocarbonyl-4-piperidin-1-yl-phenyl)-3,4-dimethoxy-benzamide
773071-41-3

N-(2-hydrazinocarbonyl-4-piperidin-1-yl-phenyl)-3,4-dimethoxy-benzamide

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

N-[2-(3,4-dimethyl-benzylidene-hydrazinocarbonyl)-4-piperidin-1-yl-phenyl]-3,4-dimethoxy-benzamide

N-[2-(3,4-dimethyl-benzylidene-hydrazinocarbonyl)-4-piperidin-1-yl-phenyl]-3,4-dimethoxy-benzamide

Conditions
ConditionsYield
acetic acid In toluene at 20 - 90℃; for 16h;96%
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

guanidine hydrogen carbonate
124-46-9, 20734-13-8, 100224-74-6, 593-85-1

guanidine hydrogen carbonate

cyclohexanone
108-94-1

cyclohexanone

(E)-8-(3,4-dimethylbenzylidene)-4-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroquinazolin-2-amine
1173717-46-8

(E)-8-(3,4-dimethylbenzylidene)-4-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroquinazolin-2-amine

Conditions
ConditionsYield
With sodium hydroxide at 70℃; for 0.25h;96%
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

dimedone
126-81-8

dimedone

aniline
62-53-3

aniline

3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-3-(3,4-dimethylphenyl)-N-phenylpropanamide
1355049-39-6

3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-3-(3,4-dimethylphenyl)-N-phenylpropanamide

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride In water at 90℃; for 12h;96%
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl (E)-2-cyano-3-(3,4-dimethylphenyl)-2-propenoate

ethyl (E)-2-cyano-3-(3,4-dimethylphenyl)-2-propenoate

Conditions
ConditionsYield
With polyacrylonitrile fiber modified with triethylenetetramine In water at 50℃; for 3h; Knoevenagel condensation;96%
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

3,4-dimethylbenzyl alcohol
6966-10-5

3,4-dimethylbenzyl alcohol

Conditions
ConditionsYield
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O); hydrogen In tert-Amyl alcohol at 30℃; under 760.051 Torr; for 12h; Green chemistry;96%
With CdS(x)Se(1-x) x:0-1;; cesium acetate; para-thiocresol In toluene Sealed tube; Inert atmosphere; Irradiation;96%
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O); isopropyl alcohol at 82℃; for 6h; Inert atmosphere; Schlenk technique; chemoselective reaction;94%
2-acetylpyridine
1122-62-9

2-acetylpyridine

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

N-Cyanoguanidine
127099-85-8, 780722-26-1

N-Cyanoguanidine

N-(4-(3,4-dimethylphenyl)-6-(pyridin-2-yl)pyrimidin-2-yl)cyanamide
1391405-52-9

N-(4-(3,4-dimethylphenyl)-6-(pyridin-2-yl)pyrimidin-2-yl)cyanamide

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 80℃; for 1h;96%
1.3-propanedithiol
109-80-8

1.3-propanedithiol

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

2-(3,4-dimethylphenyl)-m-dithiane

2-(3,4-dimethylphenyl)-m-dithiane

Conditions
ConditionsYield
With [silica-OSi(OMe)2C3H6(N2C3(CH3)H2)C4H8SO3H]HSO4 In water for 2h;96%
With boron trifluoride diethyl etherate In dichloromethane Inert atmosphere;
5-amino-1H-indole
5192-03-0

5-amino-1H-indole

3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

dimedone
126-81-8

dimedone

8,9-dihydro-8,8-dimethyl-11-(3,4-dimethylphenyl)-3H-pyrrolo[3,2-a]acridin-10(6H,7H,11H)-one
1449762-71-3

8,9-dihydro-8,8-dimethyl-11-(3,4-dimethylphenyl)-3H-pyrrolo[3,2-a]acridin-10(6H,7H,11H)-one

Conditions
ConditionsYield
In ethanol for 10h; Reflux;96%
3,4-dimethylbenzaldehyde
5973-71-7

3,4-dimethylbenzaldehyde

anthranilic acid nitrile
1885-29-6

anthranilic acid nitrile

2-(3,4-dimethylphenyl)quinazolin-4(3Η)-one
1313761-04-4

2-(3,4-dimethylphenyl)quinazolin-4(3Η)-one

Conditions
ConditionsYield
With 1,10-Phenanthroline; caesium carbonate; copper dichloride In water at 80℃; for 12h;96%
Stage #1: anthranilic acid nitrile With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; butyraldehyde oxime In para-xylene at 70℃; Schlenk technique; Inert atmosphere;
Stage #2: 3,4-dimethylbenzaldehyde In para-xylene at 110℃; for 4h; Inert atmosphere; Schlenk technique;
83%
Stage #1: anthranilic acid nitrile With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; butyraldehyde oxime In para-xylene at 70℃; for 12h; Schlenk technique;
Stage #2: 3,4-dimethylbenzaldehyde In para-xylene at 20 - 110℃; for 4h; Schlenk technique;
83%

5973-71-7Relevant articles and documents

Copper-catalyzed aerobic alcohol oxidation under air in neat water by using a water-soluble ligand

Zhang, Guofu,Han, Xingwang,Luan, Yuxin,Wang, Yong,Wen, Xin,Xu, Li,Ding, Chengrong,Gao, Jianrong

, p. 19255 - 19258 (2013)

A copper-catalyzed primary benzylic and allylic alcohols oxidation system has been developed under air in neat water by use of a water-soluble ligand (pytl-β-CD). The ligand was designed and synthesized via a click conjunction between functionalized β-cyclodextrin (β-CD) and 2-ethinylpyridine.

Organic Electrochemistry: Expanding the Scope of Paired Reactions

Moeller, Kevin D.,Wu, Tiandi

supporting information, p. 12883 - 12890 (2021/05/07)

Paired electrochemical reactions allow the optimization of both atom and energy economy of oxidation and reduction reactions. While many paired electrochemical reactions take advantage of perfectly matched reactions at the anode and cathode, this matching of substrates is not necessary. In constant current electrolysis, the potential at both electrodes adjusts to the substrates in solution. In principle, any oxidation reaction can be paired with any reduction reaction. Various oxidation reactions conducted on the anodic side of the electrolysis were paired with the generation and use of hydrogen gas at the cathode, showing the generality of the anodic process in a paired electrolysis and how the auxiliary reaction required for the oxidation could be used to generate a substrate for a non-electrolysis reaction. This is combined with variations on the cathodic side of the electrolysis to complete the picture and illustrate how oxidation and reduction reactions can be combined.

Method for preparing 3,4-dimethyl benzaldehyde by efficiently catalyzing pseudocumene

-

Paragraph 0023-0056, (2019/08/20)

The invention belongs to the technical field of polyoxometallate catalysts, and relates to a method for preparing 3,4-dimethyl benzaldehyde by catalytically oxidizing pseudocumene with a polyoxometallate (Keggin type, Dawson type, Silverton type, Waugh type, Lindquist type, Anderson type and the like) catalyst. The polyoxometallate is adopted as the catalyst, and placed in a reactor, then an organic solvent and the pseudocumene are added in sequence, finally an oxidizing agent is added, stirring and reacting are carried out for 12-48 hours at the temperature of 50 DEG C to 80 DEG C, separationis carried out, and the 3,4-dimethyl benzaldehyde is obtained. Compared with the prior art, the method is easy to operate and mild in condition, the method for preparing the 3,4-dimethyl benzaldehydehas atom economy and environmental friendliness, the conversion rate of the pseudocumene and the selectivity of the 3,4-dimethyl benzaldehyde are high, the catalyst has the advantages of being green,efficient, easy to recycle and the like, and application and popularization value is achieved.

3. 4 - Dimethyl benzaldehyde preparation method

-

Paragraph 0023-0027, (2019/05/15)

The present invention relates to the technical field of fine organic synthesis, in particular to 3, 4 - dimethyl benzaldehyde preparation method, comprising the steps of: 1) acylate: will be 100 parts by weight of ortho-xylene and 150 parts by weight of 1, 3 - dioxa cyclohexane for acidification under acidic conditions, inject the nitrogen used as a ventilation; adding 220 parts by weight of aluminum trichloride with 100 parts by weight of a mixed Lewis acid catalytic, access 120 parts by weight of carbon monoxide, acylation reaction temperature is lower than 5 °C, time is at least 12 hours; 2) water washing: washing solution after the acylate, washing temperature 0 - 5 °C; 3) distillation: oil phase distillation, the distillation temperature in the 145 °C - 225 °C between, sneaking object O-xylene condensed into liquid and enters the tank; 4) re-distillation. The present invention relates to 1, 3 - dioxa cyclohexane as solvent can be better dissolved gaseous carbon monoxide, into the special catalyst reaction can be carried out under the atmospheric pressure, to reduce the requirement of reaction equipment; accelerate the reaction speed and selective, in the product less geometric isomer, the prepared 3, 4 - dimethyl benzaldehyde high purity.

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