5973-71-7

Basic information

• Product Name: 3,4-Dimethylbenzaldehyde
• Synonyms: 3,4-DIMETHYLBENZALDEHYDE;34 DMB;DIMETHYLBENZALDEHYDE,3,4-;3,4-dimethyl-benzaldehyd;O-XYLENE-4-CARBOXALDEHYDE;Benzaldehyde, 3,4-dimethyl-;3,4-Dimethyl;DIMETHYLBENZALDEHYDE,3,4-(RG)
• CAS NO: 5973-71-7
• Molecular Formula: C₉H₁₀O
• Molecular Weight: 134.18
• EINECS: 227-770-2
• Product Categories: Benzene derivatives;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;API intermediates;Aldehydes;C9;Carbonyl Compounds
• Mol File: 5973-71-7.mol
• Article Data: 45

Chemical Properties

• Melting Point: 225-226 C
• Boiling Point: 226 °C(lit.)
• Flash Point: 225 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.012 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0871mmHg at 25°C
• Refractive Index: n20/D 1.551(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol (Slightly)
• Water Solubility: Soluble in ethanol, ether, toluene. Insoluble in water.
• Sensitive: Air Sensitive
• BRN: 1634270
• CAS DataBase Reference: 3,4-Dimethylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dimethylbenzaldehyde(5973-71-7)
• EPA Substance Registry System: 3,4-Dimethylbenzaldehyde(5973-71-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36/37-26
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 5973-71-7(Hazardous Substances Data)

Usage

Description

3,4-Dimethylbenzaldehyde (3,4-DMB) is a benzaldehyde derivative that serves as an intermediate in various chemical processes and is known for its clear, colorless to yellowish liquid appearance. It is formed as an intermediate during the transformation of furfural into gasoline-range fuels using ZSM-5-based catalysts and is also the oxidative degradation product of trimethylbenzene. 3,4-Dimethylbenzaldehyde has been studied through vibrational analysis using FT-IR and FT-Raman spectra, as well as ab initio and density functional theory (DFT) calculations.

Uses

Used in Chemical Industry:
3,4-Dimethylbenzaldehyde is used as an additive for resins, contributing to the enhancement of their properties and performance in various applications.
Used in Agriculture:
As an agricultural intermediate, 3,4-Dimethylbenzaldehyde plays a role in the development and production of various agricultural chemicals and products.
Used in Flavor and Fragrance Industry:
3,4-Dimethylbenzaldehyde is utilized in the flavor and fragrance industry to provide unique scents and flavors to a wide range of products, from perfumes to food items.
Used as a Nucleation Transparent Agent:
In the plastics and polymer industry, 3,4-Dimethylbenzaldehyde serves as a nucleation transparent agent, which helps improve the clarity and physical properties of the final products.

Flammability and Explosibility

Nonflammable

Synthetic route

3,4‐dimethylbenzaldoxime → 3,4-dimethylbenzaldehyde (5973-71-7)

3,4-dimethylbenzyl alcohol (6966-10-5) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With ammonium hydroxide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In ethanol at 50℃; for 18h;	96%
With ammonium hydroxide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(ll) bromide at 80℃; for 20h;	96%
With Iron(III) nitrate nonahydrate; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,2-dichloro-ethane at 60℃; for 3h; Schlenk technique; Green chemistry;	96%

4-(chloromethyl)-1,2-dimethylbenzene (102-46-5) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With sodium nitrate; acetic acid In water for 3h; Reflux;	92%
With potassium hydroxide; cetyltrimethylammonim bromide; potassium nitrate In water for 6h; pH=10 - 11; Reflux;	81%

(chloro)(3,4-dimethylphenyl)methyl p-tolyl sulfoxide → 3,4-dimethylbenzaldehyde (5973-71-7) + di(p-tolyl) disulfide (103-19-5) + 3,5-di(3,4-dimethylphenyl)-1,2,4,6-thiatriazine 1-oxide (307929-13-1) + 3,4-dimethylbenzonitrile (22884-95-3)

Conditions	Yield
With tetrasulphure tetranitride In 1,4-dioxane for 7h; Heating;	A n/a B 86% C 22% D n/a

3,4-dimethylbenzyl bromide (94416-66-7) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With potassium nitrite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In water for 5h; Reflux;	85%

o-xylene (95-47-6) + N,N,N',N'-tetraformylhydrazine (52023-52-6) → 3,4-dimethylbenzaldehyde (5973-71-7) + 3,4-Dimethylbenzaldehyd-azin

Conditions	Yield
Stage #1: o-xylene; N,N,N',N'-tetraformylhydrazine With aluminium trichloride In 1,2-dichloro-ethane at -15 - 1℃; for 19h; Stage #2: With water	A 9% B 77%

carbon monoxide (201230-82-2) + 3,4-dimethyliodobenzene (31599-61-8) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; formic acid; tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide at 60℃; under 760 Torr; Carbonylation; Electrochemical reaction;	76%

o-xylene (95-47-6) + tris(diformylamino)methane (332047-72-0) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
Stage #1: o-xylene; tris(diformylamino)methane With aluminium trichloride In 1,2-dichloro-ethane at -19 - 0℃; Stage #2: With water Heating;	65%
With aluminium trichloride In 1,2-dichloro-ethane at -19 - -1℃; for 15h;	42%

o-xylene (95-47-6) + tris(diformylamino)methane (332047-72-0) → 3,4-dimethylbenzaldehyde (5973-71-7) + 3,3',4,4'-tetramethyl-1,2-diphenylethane (34101-86-5)

Conditions	Yield
With aluminium trichloride In 1,2-dichloro-ethane Product distribution; Further Variations:; reagent amount;	A 64% B 3%

chloro-trimethyl-silane (75-77-4) + 3,4-dimethylbenzyl alcohol (6966-10-5) + Triphenylphosphine oxide (791-28-6) → 3,4-dimethylbenzaldehyde (5973-71-7) + Hexamethyldisiloxane (107-46-0) + triphenylphosphine (603-35-0)

Conditions	Yield
With 2,6-dimethylpyridine; tetrabutylammonium tetrafluoroborate In acetonitrile at 40℃; Electrochemical reaction;	A 61% B 10% C 72 %Spectr.

3,4-dimethylstyrene (27831-13-6) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; graphitic carbon nitride; oxygen In acetonitrile at 20℃; Inert atmosphere; Irradiation;	60%

o-xylene (95-47-6) + triformylamine (25891-31-0) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With aluminium trichloride In 1,2-dichloro-ethane at -30 - -4℃; for 12h; Formylation;	43%

ethanol (64-17-5) + 3,4-dimethylbenzyl alcohol (6966-10-5) → 3,4-dimethylbenzaldehyde (5973-71-7) + 3-(3,4-dimethylphenyl)-2-propylene aldehyde + 5-(3,4-dimethyl-phenyl)-penta-2,4-dienal

Conditions	Yield
With oxygen; potassium carbonate In 1,4-dioxane at 60℃; for 48h;	A 40% B 20% C 30%

o-xylene (95-47-6) + bis(diformylamino)methane (877680-60-9) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With aluminum (III) chloride In chlorobenzene at -12 - 18℃; for 22h;	37%

o-xylene (95-47-6) + triformylamine (25891-31-0) → 3,4-dimethylbenzaldehyde (5973-71-7) + N-[bis-(3,4-dimethyl-phenyl)-methyl]-formamide

Conditions	Yield
With aluminium trichloride In chlorobenzene at -15 - -6℃; for 16h; Product distribution; Further Variations:; Temperatures; Reagents; Solvents; ratio; addition sequence; Formylation; condensation;	A 30% B n/a

o-xylene (95-47-6) + carbon monoxide (201230-82-2) → 3,4-dimethylbenzaldehyde (5973-71-7) + 5-formyl-2,3-dimethylbenzenesulfonyl fluoride (139689-26-2)

Conditions	Yield
With antimony pentafluoride; fluorosulphonic acid at 0℃; under 760 Torr; for 96h; Yield given;	A 6% B n/a

hydrogen cyanide (74-90-8) + o-xylene (95-47-6) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With hydrogenchloride; aluminium trichloride Zersetzung des Reaktionsproduktes mit Eis und Salzsaeure;

o-xylene (95-47-6) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With aluminium trichloride; hydrogen cyanide at 100℃; Einleiten von HCl und anschliessend Behandeln mit Eis und wss. HCl;
Multi-step reaction with 2 steps 1: aluminium chloride 2: diluted alkali View Scheme
Multi-step reaction with 3 steps 1: aluminium chloride 2: diluted alkali View Scheme

1,2,4-Trimethylbenzene (95-63-6) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With manganese(IV) oxide; sulfuric acid
With sulfuric acid In acetonitrile at 50 - 80℃; for 24h; Reagent/catalyst;

3,4-dimethyl-mandelic acid (5766-03-0) → 3,4-dimethylbenzaldehyde (5973-71-7)

β-chloro-3,4-dimethyl-styrene → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With permanganate(VII) ion; acetone

2,2,2-trichloro-1-(3,4-dimethyl-phenyl)-ethanol → 3,4-dimethylbenzaldehyde (5973-71-7) + 3,4-dimethyl-mandelic acid (5766-03-0)

Conditions	Yield
With diluted alkali

3,4-dimethyl-benzoic acid-(N-methyl-anilide) (349109-03-1) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With tetrahydrofuran; lithium aluminium tetrahydride

3,4-dimethylphenylmagnesium bromide (89980-68-7) + ethyl N-phenylformimidate (6780-49-0) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With diethyl ether anschliessend mit wss.HCl;

3,4-dimethylbenzoyl chloride (21900-23-2) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With Pd-BaSO4; xylene at 140 - 150℃; Hydrogenation;

chloroform (67-66-3) + 3,4-dimethylbenzonitrile (22884-95-3) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With hydrogenchloride; diethyl ether; tin(ll) chloride Erwaermen des Reaktionsprodukts mit H2O;

methanol (67-56-1) + 4,4-dimethylcyclohexa-2,5-dienone (1073-14-9) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
titanium tetrachloride Irradiation;

(3,4-Dimethyl-phenyl)-nitromethan (33241-78-0) → 3,4-dimethylbenzaldehyde (5973-71-7)

Conditions	Yield
With potassium permanganate

o-xylene (95-47-6) + carbon monoxide (201230-82-2) → 3,4-dimethylbenzaldehyde (5973-71-7) + 2,3-dimethylbenzaldehyde (5779-93-1)

Conditions	Yield
With antimony pentafluoride; fluorosulphonic acid at 0℃; under 760 Torr; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

(4R,5R)-1-C-(1,2-dimethyl-4-nitrocyclohex-1-en-5-yl)carbaldehyde (125488-63-3) → 3,4-dimethylbenzaldehyde (5973-71-7) + 4,5-dimethylcyclohexa-1,4-diene-1-carbaldehyde (82372-64-3)

Conditions	Yield
With potassium carbonate In methanol for 1h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

3,4-dimethylbenzaldehyde (5973-71-7) + acetone (67-64-1) → (E)-4-(3,4-dimethylphenyl)but-3-en-2-one (97241-86-6)

Conditions	Yield
With sodium hydroxide In water at 0 - 25℃; for 6h;	100%
With sodium hydroxide
With sodium hydroxide In water at 25℃; for 12h;

3-{[bis-(2-hydroxy-propyl)-amino]-methyl}-N-(3-hydrazinocarbonyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-benzamide (773071-20-8) + 3,4-dimethylbenzaldehyde (5973-71-7) → 3-{[bis-(2-hydroxy-propyl)-amino]-methyl}-N-[3-(3,4-dimethyl-benzylidene-hydrazinocarbonyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]-benzamide

Conditions	Yield
In toluene at 20℃; for 15h; Heating / reflux;	100%

3,4-dimethylbenzaldehyde (5973-71-7) + cis, trans-1,3-dimethylaminocyclohexane (2579-20-6) → C26H34N2 (1217526-73-2)

Conditions	Yield
In methanol at 20℃; Molecular sieve;	100%
In methanol at 20℃; Molecular sieve;

3,4-dimethylbenzaldehyde (5973-71-7) + N-prenyl-N-propargyltosylamide (132330-44-0) → C24H29NO3S (1363388-69-5)

Conditions	Yield
Stage #1: N-prenyl-N-propargyltosylamide With ethylmagnesium bromide In tetrahydrofuran at 50℃; for 1h; Stage #2: 3,4-dimethylbenzaldehyde In tetrahydrofuran at 20℃; for 3h;	100%
Stage #1: N-prenyl-N-propargyltosylamide With ethylmagnesium bromide In tetrahydrofuran at 50℃; for 1h; Stage #2: 3,4-dimethylbenzaldehyde In tetrahydrofuran at 20℃; for 3h;

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 3,4-dimethylbenzaldehyde (5973-71-7) → (E)-ethyl 3-(3,4-dimethylphenyl)acrylate (81069-49-0, 83004-26-6)

Conditions	Yield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With lithium chloride In tetrahydrofuran at 20℃; for 0.25h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; Stage #2: 3,4-dimethylbenzaldehyde With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran Horner-Wadsworth-Emmons Olefination; Inert atmosphere;	100%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 30℃; for 4h; Glovebox;	99%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 3,4-dimethylbenzaldehyde In tetrahydrofuran

3,4-dimethylbenzaldehyde (5973-71-7) + D-sorbitol (50-70-4) → 1,3:2,4-di-O-(3,4-dimethylbenzylidene)-D-sorbitol (135861-56-2)

Conditions	Yield
toluene-4-sulfonic acid In acetonitrile at 20℃; for 12h; Product distribution / selectivity;	99%
With trimethyl orthoformate; bismuth(lll) trifluoromethanesulfonate In methanol at 20℃; for 48h; Product distribution / selectivity;	99%
With trimethyl orthoformate; bismuth(lll) trifluoromethanesulfonate In methanol at 20℃; for 49h; Product distribution / selectivity; Heating / reflux;	99%

tetrahydrofuran-2,4-dione (4971-56-6) + 1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) + 3,4-dimethylbenzaldehyde (5973-71-7) → 4-(3,4-dimethylphenyl)-3-methyl-1-phenyl-1H-furo[3,4-e]pyrazolo[3,4-b]pyridine-5(7H)-one (1173933-03-3)

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride In water at 90℃; for 10h;	97%
With 1-n-butyl-3-methylimidazolim bromide at 95℃; for 2h;	91%

3,4-dimethylbenzaldehyde (5973-71-7) + phenylboronic acid (98-80-6) → phenyl 3,4-dimethylbenzoate

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3-bis(mesityl)imidazolium chloride In dimethyl sulfoxide at 80℃; for 0.5h;	97%

3,4-dimethylbenzaldehyde (5973-71-7) → o-xylene (95-47-6) + 1,2,4-Trimethylbenzene (95-63-6)

Conditions	Yield
With palladium/alumina; hydrogen In hexane at 325℃; Flow reactor; Green chemistry;	A 96.2% B 3.8%
With hydrogen In hexane at 325℃; Flow reactor; Green chemistry;	A 15.9% B 84.2%

3,4-dimethylbenzaldehyde (5973-71-7) + 1,3-cylohexanedione (504-02-9) + 1-amino-5,5-dimethylcyclohexen-3-one (873-95-0) → (+/-)-9-(3,4-dimethylphenyl)-3,3-dimethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride In water at 100℃; for 6h;	96%

N-(2-hydrazinocarbonyl-4-piperidin-1-yl-phenyl)-3,4-dimethoxy-benzamide (773071-41-3) + 3,4-dimethylbenzaldehyde (5973-71-7) → N-[2-(3,4-dimethyl-benzylidene-hydrazinocarbonyl)-4-piperidin-1-yl-phenyl]-3,4-dimethoxy-benzamide

Conditions	Yield
acetic acid In toluene at 20 - 90℃; for 16h;	96%

3,4-dimethylbenzaldehyde (5973-71-7) + guanidine hydrogen carbonate (124-46-9, 20734-13-8, 100224-74-6, 593-85-1) + cyclohexanone (108-94-1) → (E)-8-(3,4-dimethylbenzylidene)-4-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroquinazolin-2-amine (1173717-46-8)

Conditions	Yield
With sodium hydroxide at 70℃; for 0.25h;	96%

cycl-isopropylidene malonate (2033-24-1) + 3,4-dimethylbenzaldehyde (5973-71-7) + dimedone (126-81-8) + aniline (62-53-3) → 3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-3-(3,4-dimethylphenyl)-N-phenylpropanamide (1355049-39-6)

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride In water at 90℃; for 12h;	96%

3,4-dimethylbenzaldehyde (5973-71-7) + ethyl 2-cyanoacetate (105-56-6) → ethyl (E)-2-cyano-3-(3,4-dimethylphenyl)-2-propenoate

Conditions	Yield
With polyacrylonitrile fiber modified with triethylenetetramine In water at 50℃; for 3h; Knoevenagel condensation;	96%

3,4-dimethylbenzaldehyde (5973-71-7) → 3,4-dimethylbenzyl alcohol (6966-10-5)

Conditions	Yield
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O); hydrogen In tert-Amyl alcohol at 30℃; under 760.051 Torr; for 12h; Green chemistry;	96%
With CdS(x)Se(1-x) x:0-1;; cesium acetate; para-thiocresol In toluene Sealed tube; Inert atmosphere; Irradiation;	96%
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O); isopropyl alcohol at 82℃; for 6h; Inert atmosphere; Schlenk technique; chemoselective reaction;	94%

2-acetylpyridine (1122-62-9) + 3,4-dimethylbenzaldehyde (5973-71-7) + N-Cyanoguanidine (127099-85-8, 780722-26-1) → N-(4-(3,4-dimethylphenyl)-6-(pyridin-2-yl)pyrimidin-2-yl)cyanamide (1391405-52-9)

Conditions	Yield
With sodium hydroxide In ethanol at 80℃; for 1h;	96%

1.3-propanedithiol (109-80-8) + 3,4-dimethylbenzaldehyde (5973-71-7) → 2-(3,4-dimethylphenyl)-m-dithiane

Conditions	Yield
With [silica-OSi(OMe)2C3H6(N2C3(CH3)H2)C4H8SO3H]HSO4 In water for 2h;	96%
With boron trifluoride diethyl etherate In dichloromethane Inert atmosphere;

5-amino-1H-indole (5192-03-0) + 3,4-dimethylbenzaldehyde (5973-71-7) + dimedone (126-81-8) → 8,9-dihydro-8,8-dimethyl-11-(3,4-dimethylphenyl)-3H-pyrrolo[3,2-a]acridin-10(6H,7H,11H)-one (1449762-71-3)

Conditions	Yield
In ethanol for 10h; Reflux;	96%

3,4-dimethylbenzaldehyde (5973-71-7) + anthranilic acid nitrile (1885-29-6) → 2-(3,4-dimethylphenyl)quinazolin-4(3Η)-one (1313761-04-4)

Conditions	Yield
With 1,10-Phenanthroline; caesium carbonate; copper dichloride In water at 80℃; for 12h;	96%
Stage #1: anthranilic acid nitrile With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; butyraldehyde oxime In para-xylene at 70℃; Schlenk technique; Inert atmosphere; Stage #2: 3,4-dimethylbenzaldehyde In para-xylene at 110℃; for 4h; Inert atmosphere; Schlenk technique;	83%
Stage #1: anthranilic acid nitrile With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; butyraldehyde oxime In para-xylene at 70℃; for 12h; Schlenk technique; Stage #2: 3,4-dimethylbenzaldehyde In para-xylene at 20 - 110℃; for 4h; Schlenk technique;	83%

Upstream product

• 95-63-6 1,2,4-Trimethylbenzene 
• 67-66-3 chloroform 
• 22884-95-3 3,4-dimethylbenzonitrile 
• 95-47-6 o-xylene 
• 201230-82-2 carbon monoxide 
• 31599-61-8 3,4-dimethyliodobenzene 
• 25891-31-0 triformylamine 
• 94416-66-7 3,4-dimethylbenzyl bromide 
• 175277-35-7 3,4‐dimethylbenzaldoxime 
• 89980-68-7 3,4-dimethylphenylmagnesium bromide 
• 6780-49-0 ethyl N-phenylformimidate 
• 349109-03-1 3,4-dimethyl-benzoic acid-(N-methyl-anilide) 
• 74-90-8 hydrogen cyanide 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 63407-15-8 1,1-bis-(3,4-dimethyl-phenyl)-2-nitro-ethane 
• 60521-25-7 3,4-dimethylcinnamic acid 
• 5766-03-0 3,4-dimethyl-mandelic acid 
• 175277-35-7 3,4‐dimethylbenzaldoxime 
• 97241-86-6 (E)-4-(3,4-dimethylphenyl)but-3-en-2-one 
• 90672-24-5 (3,4-Dimethyl-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 94317-93-8 (5Z,10Z,14Z,19Z)-5,10,15,20-Tetrakis-(3,4-dimethyl-phenyl)-porphyrin 
• 1855-36-3 (3,4-dimethyl-phenyl)-oxirane 
• 252961-08-3 2,4-di-tert-butyl-6-[dimethylamino-(3,4-dimethyl-phenyl)-methyl]-phenol 
• 851663-36-0 3-(3,4-dimethyl-phenyl)-1-pyridin-4-yl-propenone 

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The invention belongs to the technical field of polyoxometallate catalysts, and relates to a method for preparing 3,4-dimethyl benzaldehyde by catalytically oxidizing pseudocumene with a polyoxometallate (Keggin type, Dawson type, Silverton type, Waugh type, Lindquist type, Anderson type and the like) catalyst. The polyoxometallate is adopted as the catalyst, and placed in a reactor, then an organic solvent and the pseudocumene are added in sequence, finally an oxidizing agent is added, stirring and reacting are carried out for 12-48 hours at the temperature of 50 DEG C to 80 DEG C, separationis carried out, and the 3,4-dimethyl benzaldehyde is obtained. Compared with the prior art, the method is easy to operate and mild in condition, the method for preparing the 3,4-dimethyl benzaldehydehas atom economy and environmental friendliness, the conversion rate of the pseudocumene and the selectivity of the 3,4-dimethyl benzaldehyde are high, the catalyst has the advantages of being green,efficient, easy to recycle and the like, and application and popularization value is achieved.

3. 4 - Dimethyl benzaldehyde preparation method

The present invention relates to the technical field of fine organic synthesis, in particular to 3, 4 - dimethyl benzaldehyde preparation method, comprising the steps of: 1) acylate: will be 100 parts by weight of ortho-xylene and 150 parts by weight of 1, 3 - dioxa cyclohexane for acidification under acidic conditions, inject the nitrogen used as a ventilation; adding 220 parts by weight of aluminum trichloride with 100 parts by weight of a mixed Lewis acid catalytic, access 120 parts by weight of carbon monoxide, acylation reaction temperature is lower than 5 °C, time is at least 12 hours; 2) water washing: washing solution after the acylate, washing temperature 0 - 5 °C; 3) distillation: oil phase distillation, the distillation temperature in the 145 °C - 225 °C between, sneaking object O-xylene condensed into liquid and enters the tank; 4) re-distillation. The present invention relates to 1, 3 - dioxa cyclohexane as solvent can be better dissolved gaseous carbon monoxide, into the special catalyst reaction can be carried out under the atmospheric pressure, to reduce the requirement of reaction equipment; accelerate the reaction speed and selective, in the product less geometric isomer, the prepared 3, 4 - dimethyl benzaldehyde high purity.