94418-48-1Relevant academic research and scientific papers
Chemoselective Reactions of Isocyanates with Secondary Amides: One-Pot Construction of 2,3-Dialkyl-Substituted Quinazolinones
Lin, Yi,He, Shu-Fan,Geng, Hui,Xiao, Yu-Chen,Ji, Kan-Lei,Zheng, Jian-Feng,Huang, Pei-Qiang
, p. 5345 - 5353 (2021/04/06)
A facile method for the preparation of 2,3-dialkyl-substituted quinazolinones from readily available N-arylamides and commercial isocyanates was developed. This one-pot procedure involves the chemoselective activation of the secondary amide with Tf2O/2-Br-Pyr, the sequential addition of isocyanate, and cyclization. The mild reaction is general for a wide range of substrates and can be run on a gram scale.
Functionalized carbodiimide mediated synthesis of 2,3-disubstituted quinazolin-4(3 H)-ones via the tandem strategy of C-nucleophilic addition and intramolecular NH-substitution cyclization
Nakano, Hayato,Kutsumura, Noriki,Saito, Takao
supporting information, p. 3179 - 3184 (2012/11/14)
A facile synthesis of quinazolin-4(3H)-ones possessing carbon substituents at positions 2 and 3 has been developed. Key to the synthesis is a tandem strategy involving introduction of a 2-substituent and construction of the quinazolinone framework via C-nucleophilic addition to the carbodiimide cumulenic carbon followed by intramolecular nucleophilic substitution by the newly formed NH moiety at the proximal ester group.
PYRIMIDINE DERIVATIVES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
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Page/Page column 264, (2008/06/13)
The present invention relates to compounds of Formula (I) as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Studies on Some Biologically Active Azepinoquinazolines: Part I - An Approach to Potent Bronchodilatory Compounds
Malhotra, S.,Koul, S. K.,Sharma, R. L.,Anand, K. K.,Gupta, O. P.,Dhar, K. L.
, p. 937 - 940 (2007/10/02)
Twenty six azepinoquinazolines have been prepared and screened for their bronchodilatory activity.Out of these compounds, 7,8,9,10-tetrahydroazepinoquinazolin-12(6H)-one (III) has been found as an excellent bronchodilatory compound. 2,4,6-Tribromo-7,8,9,10-tetrahydroazepinoquinazolin-12(6H)-one (XXIV) shows marked antitussive and mucolytic activities parallel to those of bromhexine.
