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Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-2-IODOBENZONITRILE is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
4-BROMO-2-IODOBENZONITRILE is used as a crucial component in the production of agrochemicals, aiding in the creation of effective pesticides and other agricultural chemicals.
Used in Medicinal Chemistry:
4-BROMO-2-IODOBENZONITRILE is utilized as a versatile building block for the synthesis of functionalized aromatic compounds, which are essential in the advancement of medicinal chemistry.
Used in Materials Science:
4-BROMO-2-IODOBENZONITRILE is employed in the development of new materials with specific properties, such as those used in electronics, plastics, and other industries.
Used in Organic Synthesis Methods:
4-BROMO-2-IODOBENZONITRILE is used as a reagent in the development of innovative organic synthesis methods, enhancing the efficiency and effectiveness of chemical reactions.
Used in Chemical Research and Development:
4-BROMO-2-IODOBENZONITRILE is an important compound in the field of chemical research and development, playing a significant role in the discovery and creation of new chemical processes and products.

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 304858-65-9 2-amino-4-bromobenzonitrile 

Relevant academic research and scientific papers

SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES

Provided is a compound of Formula (I): wherein the variable groups are defined herein.

BIARYLMETHYL HETEROCYCLES

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF GROUP II METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides novel heterocyclic compounds of the general formula (I), including novel compounds of formula (la), and pharmaceutical compositions containing them. Moreover, the compounds of formula (I) or (la) and the pharmaceutical compo

Generation and suppression of 3-/4-functionalized benzynes using zinc ate base (TMP-Zn-ate): New approaches to multisubstituted benzenes

We present full details of our new methods for preparing functionalized benzynes with lithium di-alkyl(2,2,6,6-tetramethylpiperidino)zincate (R 2Zn(TMP)Li) through deprotonative zincation as a key reaction. In this system, by choosing appropriate ligands for the zincate, either regioselective zincation of functionalized haloaromatics or the generation of substituted benzynes can be controlled in good yields with excellent chemoselectivity, using the same substrate. Zincation with tBu 2Zn(TMP)Li followed by electrophilic trapping or zincation with Me2Zn(TMP)Li followed by nucleophilic or diene trapping is shown to be a powerful tool for the chemoselective preparation of 1,2,3-/1,2,4- trisubstituted benzene derivatives. These methods offer far greater generality than previous methods for the synthesis of multifunctionalized benzenes. Computational/theoretical studies of the reaction mechanism of this unique benzyne formation indicated that preferential coordination of the dialkylzinc moiety of zincate to halogen is the reason for the reduced activation energy of the elimination, that is, for the formation of the benzyne. The role of the ligands on Zn in accelerating/decelerating the elimination is also discussed.

PREPARATION AND USE OF MAGNESIUM AMIDES

The present application relates to mixed Mg/Li amides of the general formula R1R2N-Mg-NR3R4.zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R4 is other than H; Y is selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HaIOn, wherein n = 3 or 4 and Hal is selected from Ci, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RxCO2; an alcoholate of the general formula ORx; a thiolate of the general formula SRx; RxP(O)O2; or SCORx; or SCSRx; OnSRx, wherein n = 2 or 3; or NOn, wherein n = 2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1; and z > 1; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.