944411-92-1

Basic information

• Product Name: 4-(2-piperidin-1-ylethyl)piperidine-1-carboxylic acid (4-bromophenyl)amide
• Synonyms: 4-(2-piperidin-1-ylethyl)piperidine-1-carboxylic acid (4-bromophenyl)amide
• CAS NO: 944411-92-1
• Molecular Weight: 394.355
• Mol File: 944411-92-1.mol

Chemical Properties

• CAS DataBase Reference: 4-(2-piperidin-1-ylethyl)piperidine-1-carboxylic acid (4-bromophenyl)amide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-piperidin-1-ylethyl)piperidine-1-carboxylic acid (4-bromophenyl)amide(944411-92-1)
• EPA Substance Registry System: 4-(2-piperidin-1-ylethyl)piperidine-1-carboxylic acid (4-bromophenyl)amide(944411-92-1)

Safety Data

• Hazardous Substances Data: 944411-92-1(Hazardous Substances Data)

Upstream product

• 14759-09-2 1-(2-(piperidin-4-yl)ethyl)piperidine 
• 2493-02-9 4-bromophenyl isocyanate 
• 89151-44-0 4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 89151-45-1 tert-butyl-4-(2-(tosyloxy)ethyl)piperidine-1-carboxylate 
• 944411-91-0 4-(2-piperidin-1-ylethyl)piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 14759-09-2 1-(2-(piperidin-4-yl)ethyl)piperidine 
• 1608129-84-5 C₁₄H₁₄N₂O 
• 106-40-1 4-bromo-aniline 

Relevant articles and documents

Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor

α7 nicotinic acetylcholine receptor agonists are promising therapeutic candidates for the treatment of cognitive impairment. As a follow up of our internal medicinal chemistry program we investigated a novel series of α7 nAChR agonists. Starting from molecular docking studies on two series of molecules recently developed in our laboratories, an alternative scaffold was designed attempting to combine the optimal features of these previously identified urea and pyrazole compounds. Based on our previous SAR knowledge and on predicted drug-like properties, a small library was synthesized in parallel manner, affording compounds with excellent α7 nAChR activity, selectivity and preliminary ADME profile.

MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF

Compounds with α7 nicotinic acetylcholine receptor (α7 nAChR) agonistic activity, processes for their preparation, pharmaceutical compositions containing the same and the use thereof for the treatment of neurological and psychiatric diseases.

MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF

Compounds with α7 nicotinic acetylcholine receptor (α7 nAChR) agonistic activity, processes for their preparation, pharmaceutical compositions containing the same and the use thereof for the treatment of neurological and psychiatric diseases.