944443-33-8

Basic information

• Product Name: 2-[(Z)-1,3-BENZODIOXOL-5-YLMETHYLIDENE]-3-QUINUCLIDINONE
• Synonyms: 2-[(Z)-1,3-BENZODIOXOL-5-YLMETHYLIDENE]-3-QUINUCLIDINONE;(2Z)-2-[(2H-1,3-benzodioxol-5-yl)methylidene]-1-azabicyclo[2.2.2]octan-3-one
• CAS NO: 944443-33-8
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.28
• Mol File: 944443-33-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(Z)-1,3-BENZODIOXOL-5-YLMETHYLIDENE]-3-QUINUCLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(Z)-1,3-BENZODIOXOL-5-YLMETHYLIDENE]-3-QUINUCLIDINONE(944443-33-8)
• EPA Substance Registry System: 2-[(Z)-1,3-BENZODIOXOL-5-YLMETHYLIDENE]-3-QUINUCLIDINONE(944443-33-8)

Safety Data

• Hazardous Substances Data: 944443-33-8(Hazardous Substances Data)

Usage

Structure

Quinuclidinone derivative with a benzodioxol ring

Potential pharmacological properties

Therapeutic agent for the treatment of various medical conditions

Use

Building block in the synthesis of various pharmaceutical compounds

Significance

Unique structure and potential applications in drug discovery and development.

Upstream product

• 3731-38-2 3-Quinuclidinone 
• 120-57-0 piperonal 
• 1193-65-3 3-quinuclidinone hydrochloride 

Relevant articles and documents

Ruthenium-Catalyzed Highly Enantioselective Synthesis of cis-3-Quinuclidinols via DKR Asymmetric Transfer Hydrogenation

A method for the enantioselective synthesis of cis-3-quinuclidinols by Ru-catalyzed asymmetric transfer hydrogenation via dynamic kinetic resolution is described. The reaction proceeded under mild conditions using ammonium formate as the hydrogen donor, affording the products in high yields (up to 99%) with excellent diastereoselectivity (up to 99:1 dr) and enantioselectivity (95-99% ee). This protocol was applicable to gram-scale preparation with perfect enantioselectivity through simple recrystallization.

SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF 2- AND 2,3-SUBSTITUTED QUINUCLIDINES

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