94445-81-5

Upstream product

• 94445-85-9 C₂₂H₁₆Cl₂N₄O₂ 
• 304-20-1 hydralazine hydrochloride 
• 104-88-1 4-chlorobenzaldehyde 
• 1044569-46-1 1-hydrazinophthalazine 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 97142-38-6 N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-N'-phthalazin-1-yl-hydrazine 

Downstream Products

• 104615-50-1 2-[5-(4-Chloro-phenyl)-2H-[1,2,4]triazol-3-yl]-benzamide 
• 104615-51-2 3-(4-chlorophenyl)-5-(2-cyanophenyl)-1H-1,2,4-triazole 

Relevant academic research and scientific papers

Potential antibacterial agents: Part VI- synthesis and structure elucidation of Schiff bases derived from hydralazine

Synthesis of hydrazones (Schiff bases) of an antihypertensive drug, hydralazine was carried out. The study afforded the hitherto unreported l-[4-chlorobenzylidene]-hydrazinophthalazine (III-a), l-[benzylidene]- hydrazinophthalazine (III-b), l-[4-nitrobenzylidene]-hydrazinophthalazine (III-c), l-[2-nitrobenzylidene]-hydrazinophthalazine (III-d), 3-[4-chlorophenyl]-s-triazolo [3-4-a] phthalazine (IV-a) and 3-phenyl-s-triazolo [3-4-a] phthalazine (IV-b). The structures of these compounds were established using spectroscopic techniques i.e. IR, UV, 1HNMR, EIMS, FD and HRMS. Antibacterial activity of the drugs was evaluated.

Hypervalent iodine mediated synthesis of 3-substituted-s-triazolo phthalazines

Phthalazine hydrazones 1a-g on oxidation with iodobenene diacetate (IBD) in dichloromethane yield exclusively the 3-substituted-s-triazolophthalazines 2a-g.

Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses

[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula STR1 wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N--R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N--R3.