944451-16-5

Basic information

• Product Name: 4-((tert-butyldiphenylsilyl)oxy)-2-methylbutan-2-ol
• Synonyms: 4-((tert-butyldiphenylsilyl)oxy)-2-methylbutan-2-ol
• CAS NO: 944451-16-5
• Molecular Weight: 342.554
• Mol File: 944451-16-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-((tert-butyldiphenylsilyl)oxy)-2-methylbutan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((tert-butyldiphenylsilyl)oxy)-2-methylbutan-2-ol(944451-16-5)
• EPA Substance Registry System: 4-((tert-butyldiphenylsilyl)oxy)-2-methylbutan-2-ol(944451-16-5)

Safety Data

• Hazardous Substances Data: 944451-16-5(Hazardous Substances Data)

Upstream product

• 177606-52-9 tert-butyl((3-methylbut-3-en-1-yl)oxy)diphenylsilane 
• 1219000-93-7 5,5,10,10-tetramethyl-9,9-diphenyl-2,4,8-trioxa-9-silaundecane 
• 2568-33-4 3-methyl-butane-1,3-diol 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 925665-84-5 4-(tert-butyldiphenylsiloxy)-2-methylbutan-2-yl diphenylphosphinite 
• 1219000-93-7 5,5,10,10-tetramethyl-9,9-diphenyl-2,4,8-trioxa-9-silaundecane 

Relevant articles and documents

Direct Photoexcitation of Ethynylbenziodoxolones: An Alternative to Photocatalysis for Alkynylation Reactions**

Ethynylbenziodoxolones (EBXs) are commonly used as radical traps in photocatalytic alkynylations. Herein, we report that aryl-substituted EBX reagents can be directly activated by visible light irradiation. They act as both oxidants and radical traps, alleviating the need for a photocatalyst in several reported EBX-mediated processes, including decarboxylative and deboronative alkynylations, the oxyalkynylation of enamides and the C?H alkynylation of THF. Furthermore, the method could be applied to the synthesis of alkynylated quaternary centers from tertiary alcohols via stable oxalate salts and from tertiary amines via aryl imines. A photocatalytic process using 4CzIPN as an organic dye was also developed for the deoxyalkynylation of oxalates.

NOVEL PHARMACEUTICAL COMPRISING HETEROAROMATIC AMIDE DERIVATIVE OR SALT THEREOF

PROBLEM TO BE SOLVED: To provide a compound useful for treating or preventing disease associated with voltage-dependent sodium channel (Nav1.7) such as disease involving a pain, disease involving an itch, autonomic nerve-associated disease, or a pharmaceutical composition thereof. SOLUTION: The present disclosure provides a compound illustrated by the following formula, and a pharmaceutical composition containing the same. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

A facile method for the rapid and selective deprotection of methoxymethyl (MOM) ethers

We describe a rapid and efficient method for selective deprotection of methoxymethyl (MOM) ethers using ZnBr2 and n-PrSH, which completely removed MOM from diverse MOM ethers of primary, secondary, and tertiary alcohols or phenol derivatives. The deprotection takes less than ten minutes with both high yield and selectivity in the presence of other protecting groups. In addition, the rapid deprotection of MOM ethers of tertiary hydroxyls in high yield with no epimerization allows MOM to be a suitable protecting group for tertiary alcohols.