177606-52-9

Basic information

• Product Name: tert-butyl((3-methylbut-3-en-1-yl)oxy)diphenylsilane
• Synonyms: tert-butyl((3-methylbut-3-en-1-yl)oxy)diphenylsilane
• CAS NO: 177606-52-9
• Molecular Weight: 324.538
• Mol File: 177606-52-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: tert-butyl((3-methylbut-3-en-1-yl)oxy)diphenylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl((3-methylbut-3-en-1-yl)oxy)diphenylsilane(177606-52-9)
• EPA Substance Registry System: tert-butyl((3-methylbut-3-en-1-yl)oxy)diphenylsilane(177606-52-9)

Safety Data

• Hazardous Substances Data: 177606-52-9(Hazardous Substances Data)

Upstream product

• 763-32-6 2-methyl-1-buten-4-ol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 188263-82-3 1-((tert-butyldiphenylsilyl)oxy)-3-methyl-2-butene 

Downstream Products

• 188263-82-3 1-((tert-butyldiphenylsilyl)oxy)-3-methyl-2-butene 
• 1345135-38-7 (7R,11R,15R)-16-tert-butyldimethylsilyloxy-1-tert-butyldiphenylsilyloxy-11-hydroxy-5-phenylsulfonyl-3,7,11,15-tetramethyl-4-hexadecanone 
• 1345135-16-1 (7R,11R,15R)-16-tert-butyldimethylsilyloxy-1-tert-butyldiphenylsilyloxy-11-hydroxy-3,7,11,15-tetramethyl-4-hexadecanone 
• 126616-47-5 4-tert-butyldiphenylsilyloxy-2-methylbutan-1-al 
• 204316-52-9 4-(tert-butyldiphenylsilyloxy)-2-methylbutan-1-ol 
• 1454661-34-7 diethyl 4-((tert-butyldiphenylsilyl)oxy)-2-fluoro-2-methylbutylphosphonate 
• 944451-16-5 4-((tert-butyldiphenylsilyl)oxy)-2-methylbutan-2-ol 
• 1613059-61-2 4-hydroxy-2-methylenebutyl 4-(dimethylamino)benzoate 
• 1613059-42-9 (S)-4-fluoro-2-hydroxy-2-(hydroxymethyl)butyl 4-(dimethylamino)benzoate 
• 1613059-41-8 (S)-4-chloro-2-hydroxy-2-(hydroxymethyl)butyl 4-(dimethylamino)benzoate 
• 1613059-40-7 (S)-4-((tert-butyldimethylsilyl)oxy)-2-hydroxy-2-(hydroxymethyl)butyl 4-(dimethylamino)benzoate 

Relevant articles and documents

Addition of vinylmetallic reagents to chiral 2-formyltetrahydrofuran

Polyketide macrolides, which belong to an interesting family of metabolites, are complex structures with valuable bioactivity. In this work, several procedures for the bond formation between a vinylorganometallic reagent and a chiral formyl-THF compound were examined for the subsequent application to the total synthesis of phormidolides. Model molecules were synthesized to study and optimize the method that mimics the union of the polyhydroxy chain with the macrocycle of the target polyketide macrolides. A chelation-controlled organometallic addition, a carboalumination, and the Nozaki-Hiyama-Kishi (NHK) reaction were the three chosen reactions to investigate this bond formation. Satisfactory diastereoselectivity and yields were obtained.

TRICYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS

The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, R5, R6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

Stereoselective alkene isomerization over one position

Although controlling both the position of the double bond and E:Z selectivity in alkene isomerization is difficult, 1 is a very efficient catalyst for selective mono-isomerization of a variety of multifunctional alkenes to afford >99.5% E-products. Many reactions are complete within 10 min at room temperature. Even sensitive enols and enamides susceptible to further reaction can be generated. Catalyst loadings in the 0.01-0.1 mol% range can be employed. E-to-Z isomerization of the product from diallyl ether was only -6 times as fast as its formation, showing the extremely high kinetic selectivity of 1.