94447-22-0

Upstream product

• 4027-57-0 ethyl 5-methyl-2H-pyrazole-3-carboxylate 
• 100-52-7 benzaldehyde 
• 40535-14-6 3-methyl-1H-pyrazole-5-carbohydrazide 
• 40535-14-6 5-methyl-1H-pyrazole-3-carboxylic acid hydrazide 

Downstream Products

• 97333-27-2 copper(II)(N-benzylidene-5-methylpyrazole-3-carbohydrazide)2(sulphate) 
• 6736-45-4 5-methyl-1⁽²⁾H-pyrazole-3-carboxylic acid N'-benzyl-hydrazide 

Relevant academic research and scientific papers

Cobalt(II), Nickel(II) and Copper(II) Complexes of N-Benzylidene-5(3)-methylpyrazole-3(5)-carbohydrazide Schiff Base

N-Benzylidene-5(3)-methylpyrazole-3(5)-carbohydrazide schiff base (BMPCH) has been synthesised and its complexes with Co(II), Ni(II) and Cu(II) have been prepared.The solid metal complexes have been characterised by various physicochemical techniques.Magnetic and electronic spectral data indicate that the bis-complexes, M(BMPCH)2X2*nH2O are grossly octahedral except the halocomplexes of cobalt(II) which may be considered as mixtures of octahedral and tetrahedral species in the light of available data.The IR spectra indicate that in the bis-derivatives, the ligand exhibits neutral tridentate (NON) behaviour coordinating through the tertiary nitrogen of the pyrazole ring, the ketonic oxygen and the azomethine nitrogen of the hydrazide component.The counterions (X) are ionic in character.

Pyrazolecarboxylic acid hydrazides as antiinflammatory agents. New selective lipoxygenase inhibitors

The synthesis and antiinflammatory activity of some new pyrazolecarboxylic acid hydrazides 3, 4 and 5 substituted with alkyl, alkylidene, aryl and acyl groups are described. 3 were prepared by reaction of pyrazolecarboxylic acids, esters, acid chlorides or diketopiperazines with hydrazines. Upon reaction with carbonyl compounds 3 gave hydrazones 4. Acylation of 3 yielded mono or bisacyl compounds 5. The most potent antiinflammatory compounds were among the N'-aryl hydrazides. These showed high lipoxygenase inhibitory activity but hardly inhibited cyclooxygenase enzyme.