94447-70-8Relevant academic research and scientific papers
Synthesis of 3-Acyl-isoxazoles and δ2-Isoxazolines from Methyl Ketones, Alkynes or Alkenes, and tert-Butyl Nitrite via a Csp3-H Radical Functionalization/Cycloaddition Cascade
Dai, Peng,Tan, Xin,Luo, Qian,Yu, Xiang,Zhang, Shuguang,Liu, Fang,Zhang, Wei-Hua
supporting information, p. 5096 - 5100 (2019/07/03)
A novel metal-free tandem Csp3-H bond functionalization of ketones and 1,3-dipolar cycloaddition has been developed. An efficient approach to a variety of oxazole and isoxazoline derivatives is demonstrated using the 1,3-dipolar cycloaddition o
Exploiting the 1,3-dithiane of 2-oxopropanenitrile oxide to limit competing dimerization in 1,3-dipolar cycloaddition reactions
Barrow, Stuart J.,Easton, Christopher J.,Savage, G. Paul,Simpson, Gregory W.
, p. 2175 - 2178 (2007/10/03)
The 1,3-dithiane of 2-oxopropanenitrile oxide is less prone to dimerization than the parent compound and, as a consequence, it undergoes more efficient cycloaddition reactions with a range of mono- and 1,1- and 1,2-di-substituted alkenes.
ALKALI METAL FLUORIDE PROMOTED GENERATION OF NITRILE OXIDES FROM HYDROXIMOYL CHLORIDES
Kim, Jae Nyoung,Chung, Kun Hoe,Ryu, Eung K.
, p. 477 - 480 (2007/10/02)
Some nitrile oxides were generated from hydroximoyl chlorides by alkali metal fluoride in the presence of methyl acrylate to give isoxazoline derivatives 2 in high yields.
1,3-DIPOLAR CYCLOADDITION: MOLECULAR SIEVES ASSISTED GENERATION OF NITRILE OXIDES FROM HYDROXIMOYL CHLORIDES
Kim, Jae Nyoung,Ryu, Eung K.
, p. 1693 - 1697 (2007/10/02)
Molecular sieves irrespective of their pore size convert hydroximoyl chlorides into the corresponding nitrile oxides very slowly and cleanly in the presence of dipolarophiles to give isoxazolines in good to excellent yields.
AN IMPROVED PROCEDURE FOR THE PREPARATION OF 2-ISOXAZOLINES
Larsen, Karl Erik,Torssell, Kurt B. G.
, p. 2985 - 2988 (2007/10/02)
Aldoximes were converted in high yields by N-Chlorosuccinimide into hydroxamic acid chlorides, and corresponding nitrile oxides generated by addition of triethylamine at 40-50 deg C underwent 1,3-dipolar addition to alkenes, giving 2-isoxazolines.The whole procedure could be performed as a one-pot reaction.Oximes with other functions, sensitive to free chlorine could be converted selectively into hydroxamic acid chlorides by this procedure.Isopropylidene glyceraldoxime was added to acrolein diethylacetal thus affording an entrance to carbohydrate synthesis but the stereospecificity of the reaction is low. 2:3, 5:6-Di-O-isopropylidene-D- mannose oxime was converted to the N-hydroximinolactone by treatment with NCS and base.
