944472-31-5

Upstream product

• 850694-33-6 methyl 3-(2'-bromo-6'-nitrophenyl)-2-oxobut-3-enoate 
• 850694-42-7 3-(2-bromo-6-nitro-phenyl)-2-oxo-but-3-enoic acid 
• 862718-99-8 methyl 3-(2'-bromo-6'-nitrophenyl)-2-oxopropanoate 
• 944472-26-8 tert-butyl (4S)-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 944472-27-9 (1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethanamine 
• 478937-33-6 ethyl (S)-2-(3-t-butoxycarbonyl-2,2-dimethyl-1,3-oxazolidin-4-yl)-1,3-thiazole-4-carboxylate 
• 55289-35-5 2-bromo-6-nitrotoluene 
• 944472-28-0 tert-butyl (4S)-4-{4-[({(1S)-2-hydroxy-1-[4-(methoxymethyl)-1,3-triazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 

Downstream Products

• 944472-32-6 (2S)-2-{[(2-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-hydroxyethyl}-1,3-thiazol-4-yl)carbonyl]amino}-2-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl 3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoate 

Relevant academic research and scientific papers

New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems

A new synthetic method providing expedient access to a wide range of polyfunctionalized N-hydroxyindoles (IV) is reported. These unique constructs are assembled by nucleophilic additions to in situ generated α,β-unsaturated nitrones (III) through carbon-carbon and carbon-heteroatom bond formation. The new synthetic technology was applied to the synthesis of nocathiacin I (1) model systems (2 and 3a-c) containing the N-hydroxyindole structural motif.