944472-33-7Relevant articles and documents
New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems
Nicolaou,Estrada, Anthony A.,Freestone, Graeme C.,Lee, Sang Hyup,Alvarez-Mico, Xavier
, p. 6088 - 6114 (2008/02/04)
A new synthetic method providing expedient access to a wide range of polyfunctionalized N-hydroxyindoles (IV) is reported. These unique constructs are assembled by nucleophilic additions to in situ generated α,β-unsaturated nitrones (III) through carbon-carbon and carbon-heteroatom bond formation. The new synthetic technology was applied to the synthesis of nocathiacin I (1) model systems (2 and 3a-c) containing the N-hydroxyindole structural motif.