94458-73-8

Upstream product

• 94458-77-2 1-chloro-3-heptanone ethylene ketal 
• 94458-71-6 1-iodo-3,3-(ethylenedioxy)heptane 
• 111-30-8 Glutaraldehyde 
• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 
• 56613-80-0 D-2-phenylglycinol 
• 94458-72-7 (3R,8aR)-5-[2-(2-Butyl-[1,3]dioxolan-2-yl)-ethyl]-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile 

Downstream Products

• 94458-75-0 (R)-2-{(2R,6R)-2-[2-(2-Butyl-[1,3]dioxolan-2-yl)-ethyl]-6-methyl-piperidin-1-yl}-2-phenyl-ethanol 
• 94535-26-9 (R)-2-{(2R,6S)-2-[2-(2-Butyl-[1,3]dioxolan-2-yl)-ethyl]-6-methyl-piperidin-1-yl}-2-phenyl-ethanol 
• 94458-74-9 (R)-2-{(R)-2-[2-(2-Butyl-[1,3]dioxolan-2-yl)-ethyl]-piperidin-1-yl}-2-phenyl-ethanol 

Relevant academic research and scientific papers

Asymmetric Synthesis. 2. Practical Method for the Asymmetric Synthesis of Indolizidine Alkaloids: Total Synthesis of (-)-Monomorine I

The alkylation of the chiral 2-cyano-6-oxazolopiperidine synthon (1) with the iodo ketal 2 gave, after selective cleavage of the cyano group, the oxazolopiperidine 4 having the 2S configuration.Compound 4 was alkylated with CH3MgI, giving a 4:1 mixture of