944716-73-8

Basic information

• Product Name: (2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide hydrochloride
• Synonyms: (2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide hydrochloride;(2S,3S)-3-Amino-N-Cyclopropyl-2-Hydroxyhexanamide HCl Salt;Hexanamide, 3-amino-N-cyclopropyl-2-hydroxy-, hydrochloride (1:1), (2S,3S)-
• CAS NO: 944716-73-8
• Molecular Formula: C₉H₁₈N₂O₂*ClH
• Molecular Weight: 222.71236
• Mol File: 944716-73-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.17 at 20℃
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide hydrochloride(944716-73-8)
• EPA Substance Registry System: (2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide hydrochloride(944716-73-8)

Safety Data

• Hazardous Substances Data: 944716-73-8(Hazardous Substances Data)

Usage

General Description

(2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride is a chemical compound that contains an amino group, a cyclopropyl group, and a hydroxy group. It is a hydrochloride salt, meaning it is in a crystalline form with a positively charged ion and a negatively charged ion. (2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride has potential applications in pharmaceutical research and development due to its unique structure and potential for interactions with biological systems. As a hydrochloride salt, it is likely to be water-soluble and stable, which may make it suitable for use in medicinal formulations. Further research is needed to fully understand the properties and potential uses of this compound.

Upstream product

• 928-95-0 (E)-2-Hexen-1-ol 
• 111003-36-2 ((2R,3S)-3-propyloxiran-2-yl)methanol 
• 959709-83-2 (4S,5S)-N-cyclopropyl-2-methyl-4-propyl-4,5-dihydro-1,3-oxazole-5-carboxamide 
• 959709-91-2 (4S,5S)-N-cyclopropyl-2-isopropyl-4-propyl-4,5-dihydro-1,3-oxazole-5-carboxamide 
• 944716-71-6 (2S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide 
• 950842-31-6 (2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide deoxycholic acid salt 

Downstream Products

• 402959-36-8 C₃₆H₅₅N₇O₆ 
• 402957-28-2 (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide 
• 1187162-81-7 (2S,4R)-tert-butyl 2-((2S,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-ylcarbamoyl)-4-(7-methoxy-2-(1H-pyrazol-1-yl)quinolin-4-yloxy)pyrrolidine-1-carboxylate 

Relevant articles and documents

Asymmetric synthesis of 3,4-disubstituted proline derivatives: Application in synthesis of hepatitis C virus protease inhibitor telaprevir

A practical asymmetric synthesis of 3,4-disubstituted proline derivatives has been realized with high stereoselectivity and moderate yield. The key steps involved are desymmetric ring-opening reaction of commercially available anhydrides, intramolecular Strecker reaction and thermodynamically controlled cyanide hydrolysis. Based on this methodology, the synthesis of HCV protease inhibitor Telaprevir was achieved.

PROCESS FOR PRODUCTION OF BETA-AMINO-ALPHA-HYDROXY ACID AMIDE DERIVATIVE

Provided is a process for production of a β-amino-α-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a β-(N-protected)amino-α-hydroxycarboxylic acid is reacted with an amine to conversion to a β-(N-protected)amino-α-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a β-amino-α-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity β-amino-α-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.

Deuterated hepatitis C protease inhibitors

A deuterated α-ketoamido steric specific compound of the formula wherein D denotes a deuterium atom on a steric specific carbon atom.