94473-25-3

Usage

Structure

A hydroxyl group (-OH) attached to a two-carbon ethyl chain (-CH2-) and a dipentylamino group ((C5H11)2N-). The presence of the hydroxyl and dipentylamino groups gives the compound its unique properties.

Physical Properties

2-(dipentylamino)ethanol is a clear liquid with a faint odor.

Uses

It is commonly used as a surfactant and emulsifier in personal care and industrial products, as an anti-static agent and corrosion inhibitor, and in the formulation of specialty lubricants. It is also utilized in some pharmaceutical and agricultural applications.

Toxicity

It is considered to be relatively low in toxicity, but proper handling and storage procedures should still be followed to ensure safety.

InChI:InChI=1/C12H27NO/c1-3-5-7-9-13(11-12-14)10-8-6-4-2/h14H,3-12H2,1-2H3

Upstream product

• 110-53-2 1-Bromopentane 
• 141-43-5 ethanolamine 

Relevant academic research and scientific papers

Structural exploration of hydrophobic core in polycationic micelles for improving siRNA delivery efficiency and cell viability

Improving siRNA delivery efficiency often encounters a dilemma with poor or decreased biocompatibility for polycationic micelles. To address this dilemma, this work focused on a structural exploration of the hydrophobic core in amphiphilic polycationic micelles by preparing two amphiphilic polycations with block or random hydrophobic segments, poly(ethylene glycol)-block-poly(aminoethyl methacrylate)-block-poly(2-diamylamine ethyl methacrylate)-block-poly(2-diethylamine ethyl methacrylate) (mPEG-PAMA-PD5A-PDEA, PADE) and poly(ethylene glycol)-block-poly(aminoethyl methacrylate)-block-poly(2-diamylamine ethyl methacrylate-co-2-diethylamine ethyl methacrylate) (mPEG-PAMA-P(D5A/DEA), PA(D/E)). The properties of the two copolymers and their self-assembly micelles were characterized, including structure, morphology, size and zeta potential. Cytotoxicity, siRNA silencing efficiency and cellular uptake of PADE/siRNA and PA(D/E)/siRNA complexes were evaluated in HepG2 and MDA-MB-231 cells in vitro. The endosome escape and intracellular distribution of PADE/siRNA and PA(D/E)/siRNA in HepG2 cells were also observed by CLSM. Significantly, the results indicated that PA(D/E)/siRNA showed not only better gene silencing efficiency but also lower cytotoxicity, which may be attributed to the homogeneous morphology of the hydrophobic core of PA(D/E) micelles. Therefore, this work provides a new pathway to overcome the dilemma between siRNA delivery efficiency and biocompatibility for the development of efficient polycation carriers.