944808-10-0

Basic information

• Product Name: tert-butyl 4-(2-chloro-5-fluorophenoxy)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(2-chloro-5-fluorophenoxy)piperidine-1-carboxylate
• CAS NO: 944808-10-0
• Molecular Formula: C₁₆H₂₁ClFNO₃
• Molecular Weight: 329.7942432
• Mol File: 944808-10-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 4-(2-chloro-5-fluorophenoxy)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(2-chloro-5-fluorophenoxy)piperidine-1-carboxylate(944808-10-0)
• EPA Substance Registry System: tert-butyl 4-(2-chloro-5-fluorophenoxy)piperidine-1-carboxylate(944808-10-0)

Safety Data

• Hazardous Substances Data: 944808-10-0(Hazardous Substances Data)

Upstream product

• 3827-49-4 2-chloro-5-fluoro-phenol 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors

A series of structurally novel stearoyl-CoA desaturase1 (SCD1) inhibitors has been identified via molecular scaffold manipulation. Preliminary structure-activity relationship (SAR) studies led to the discovery of potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitors. 4-(2-Chlorophenoxy)-N-[3-(methyl carbamoyl)phenyl]piperidine-1-carboxamide 4c exhibited robust in vivo activity with dose-dependent desaturation index lowering effects.