944916-43-2Relevant academic research and scientific papers
Palladium-catalyzed direct functionalization of imidazolinone: Synthesis of dibromophakellstatin
Lu, Jianming,Tan, Xianghui,Chen, Chuo
, p. 7768 - 7769 (2008/02/07)
The direct C-H functionalization of imidazolinone is achieved with Pd(OAc)2/NaOAc in DMSO. Dibromophakellstatin can be synthesized in five steps with 40% overall yield using this new C-H activation method. Copyright
Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists
Gore, Vijay K.,Ma, Vu V.,Tamir, Rami,Gavva, Narender R.,Treanor, James J.S.,Norman, Mark H.
, p. 5825 - 5830 (2008/04/03)
A novel series of 4,5-biarylimidazoles as TRPV1 antagonists were designed based on the previously reported 4,6-disubstituted benzimidazole series. The analogs were evaluated for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells. These studies led to the identification of a highly potent and orally bioavailable TRPV1 antagonist, imidazole 33.
