5918-93-4Relevant academic research and scientific papers
CYCLOADDITION REACTIONS OF 1,3-DIACETYLIMIDAZOLIN-2-ONE
Whitney, Ralph A.
, p. 2063 - 2066 (1981)
1,3-Diacetylimidazolin-2-one, for wich a new preparation is described, has been found to undergo thermal cycloaddition reactions with a limited number of dienes; in contrast it undergoes photochemical cycloadditions quite readily.
Stabilization of radicals by imides. A modular stereoselective approach to protected functional 1,2-diamines
Han, Songzhe,Zard, Samir Z.
, p. 5386 - 5389 (2014)
(Chemical Equation Presented) Radical addition of various xanthates to N,N′-diacylimidazol-2-one occurs readily to give protected 1,2-diamines. The imide group stabilizes the adduct radical sufficiently to enable a second addition to unactivated alkenes. In some cases, the addition product could be converted into an indoline, a tetralone, or further added to an indole. Regioselective removal of one acyl group could also be accomplished.
Synthesis of norbornahemicucurbiturils
Fiala, Tomas,Sindelar, Vladimir
, p. 2443 - 2445 (2013)
Ethyleneurea fused with a norbornane ring was prepared. Acid-catalyzed polycondensation of the urea with paraformaldehyde yielded a new six-membered hemicucurbituril derivative. The presence of hemicucurbiturils containing from four to eight monomer units were also detected. Georg Thieme Verlag Stuttgart, New York.
Lewis Acid Catalyzed Enantioselective Desymmetrization of Donor–Acceptor meso-Diaminocyclopropanes
Perrotta, Daniele,Wang, Ming-Ming,Waser, Jér?me
supporting information, p. 5120 - 5123 (2018/03/27)
The first Lewis acid catalyzed enantioselective ring-opening desymmetrization of a donor–acceptor meso-diaminocyclopropane is reported. The copper(II)-catalyzed Friedel–Crafts alkylation of indoles and one pyrrole with an unprecedented meso-diaminocyclopropane delivered enantioenriched, diastereomerically pure urea products, which are structurally related to natural and synthetic bioactive compounds. The development of a new ligand through the investigation of an underexplored subclass of bis(oxazoline) ligands was essential for achieving high enantioselectivities.
Schwartz reagent mediated synthesis of thiazolones and imidazolones from thiazolidine-2,4-diones and imidazolidine-2,4-diones
Dandepally, Srinivasa Reddy,Elgoummadi, Radouane,Williams, Alfred L.
, p. 925 - 928 (2013/02/25)
A novel reduction/elimination method of thiazolidine-2,4-dione and imidazolidine-2,4-dione derivatives using Schwartz reagent to synthesize numerous thiazolones and imidazolones in a single step is reported.
Synthesis of N-heterocyclic compounds via ene-yne metathesis reactions
Groaz, Elisabetta,Banti, Donatella,North, Michael
, p. 204 - 218 (2008/03/28)
Propargylamino and allylamino derivatives of cyclohexene and norbornene were subjected to tandem metathesis reactions with first and second generation Grubbs' catalysts 1 and 2. Results show that the method is compatible with suitably protected nitrogen-containing compounds. Cyclohexenes gave intriguing results in terms of the possibility to perform ring rearrangement metathesis (RRM) reactions, showing a difference with the analogous allyl and propargyl ether substrates.
Substituted heterocycles
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, (2008/06/13)
Compounds of formula I STR1 wherein Q1, Q2, Q3, Q4 and Q5 have any of the meanings given in the specification, their N-oxides, and their pharmacuetically acceptable salts are nonpeptide antagonists NKA, useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
Synthesis and characterization of 1,2,3,4-cyclobutanetetranitramine derivatives
Fischer, John W.,Hollins, Richard A.,Lowe-Ma, Charlotte K.,Nissan, Robin A.,Chapman, Robert D.
, p. 9340 - 9343 (2007/10/03)
A series of new nitramines have been synthesized. All of the new compounds possess four nitramine moieties arranged about a cyclobutane ring in a 1α,2α,3β,4β (cis,trans,cis) configuration. One of the new materials, 1, is unusually thermally and hydrolytically stable but sensitive to impact. 1,2,3,4-Cyclobutanetetranitramine (3) is reported for the first time.
Synthesis and Biological Activity of 9-Mercaptodethiobiotin - a Putative Biotin Precursor in Escherichia coli
Baxter, Robert L.,Camp, Dominic J.,Coutts, Andrew,Shaw, Nicholas
, p. 255 - 258 (2007/10/02)
A total synthesis of (+/-)-9-mercaptodethiobiotin 3 via the aldehyde 9 is described.Compound (+/-)-3 does not function as a biotin replacement factor for an E. coli mutant (SA291) lacking the entire biotin synthesis operon (bioABFCD-) but supports growth of an E. coli bioA mutant.Compound (+/-)-3 also supports growth of transformed cells of SA291 carrying a plasmid encoding the E. coli biotin synthase (bioB) gene indicating that the compound may be able to substitute for dethiobiotin 2 as a substrate for biotin synthase.
1-Hydroxyimidazole Derivatives; I. Synthesis of 1-Hydroxy- and 1-Alkoxy-2,3-dihydroimidazole-2-ones
Bock, Veronika,Kloetzer, Wilhelm,Singewald, Nicolas,Strieder, Georg
, p. 1058 - 1060 (2007/10/02)
Two alternative methods (A,B) are applied to prepare new 1-hydroxy- and 1-alkoxy-2,3-dihydroimidazole-2-ones.One of the favorable educts, 2,2-diethoxyethyl isocyanate, is obtained by a convenient method.
