944936-56-5Relevant academic research and scientific papers
Pyridinylimidazoles as dual glycogen synthase kinase 3β/p38α mitogen-activated protein kinase inhibitors
Heider, Fabian,Ansideri, Francesco,Tesch, Roberta,Pantsar, Tatu,Haun, Urs,D?ring, Eva,Kudolo, Mark,Poso, Antti,Albrecht, Wolfgang,Laufer, Stefan A.,Koch, Pierre
, p. 309 - 329 (2019/05/15)
Compounds simultaneously inhibiting two targets that are involved in the progression of the same complex disease may exhibit additive or even synergistic therapeutic effects. Here we unveil 2,4,5-trisubstituted imidazoles as dual inhibitors of p38α mitoge
Chiral sulfoxides as metabolites of 2-thioimidazole-based p38α mitogen-activated protein kinase inhibitors: Enantioselective synthesis and biological evaluation
Bühler, Stefanie,Goettert, Marcia,Schollmeyer, Dieter,Albrecht, Wolfgang,Laufer, Stefan A.
supporting information; experimental part, p. 3283 - 3297 (2011/06/26)
Figure Presented. A number of pharmaceutically important drugs contain asymmetric sulfinyl moieties, so the biological evaluation of chiral sulfoxides as human drug metabolites is important for the development of safe and effective pharmaceuticals. Asymme
Tri- and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors
Laufer, Stefan,Hauser, Dominik,Stegmiller, Thomas,Bracht, Claudia,Ruff, Kathrin,Schattel, Verena,Albrecht, Wolfgang,Koch, Pierre
scheme or table, p. 6671 - 6675 (2010/12/19)
The synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles as potent p38α mitogen-activated protein kinase inhibitors is described. The trisubstituted imidazole series was found to be more potent than the tetrasubstituted imidazole seri
