549505-59-1

Upstream product

• 556-64-9 methyl thiocyanate 
• 461-87-0 2-fluoro-4-methylpyridine 
• 581098-38-6 4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 
• 457081-00-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)-2-(hydroxyimino)-ethan-1-one 
• 302839-09-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)ethan-1-one 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 549505-66-0 2-fluoro-4-[4-(4-fluorophenyl)-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridine 
• 549505-65-9 ML 3403 
• 1041850-92-3 4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]-2-(tetrahydrofuran-2-ylmethoxy)pyridine 
• 1041850-59-2 {4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-pyridin-4-ylmethylamine 
• 1041850-83-2 2-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-ylamino}-butan-1-ol 
• 1041850-39-8 {4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-(2-phenylpropyl)amine 
• 1041850-54-7 benzo[b]thiophen-2-ylmethyl-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine 
• 1041850-82-1 2-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-ylamino}-propan-1-ol 
• 1041850-84-3 2-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-ylamino}-3-methylbutan-1-ol 
• 1041850-56-9 {4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-(5-methylfuran-2-ylmethyl)amine 
• 1041850-38-7 {4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-(1,2,3,4-tetrahydronaphthalen-1-yl)amine 
• 1041850-91-2 4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]-2-p-tolyloxy-pyridine 
• 1041850-70-7 {4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-(2-methylbutyl)amine 
• 1041850-75-2 (1,3-dimethylbutyl)-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine 

Relevant academic research and scientific papers

Chiral sulfoxides as metabolites of 2-thioimidazole-based p38α mitogen-activated protein kinase inhibitors: Enantioselective synthesis and biological evaluation

Figure Presented. A number of pharmaceutically important drugs contain asymmetric sulfinyl moieties, so the biological evaluation of chiral sulfoxides as human drug metabolites is important for the development of safe and effective pharmaceuticals. Asymme

A concise and optimized four-step approach toward 2-(aryl-)alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazoles using alkyl- or arylalkyl thiocyanates

A convenient cyclization method leading to trisubstituted imidazoles in up to 84% yield is reported. Diverse 1-aryl-, 2-heteroaryl-substituted ethanones are converted into the corresponding α-oximino derivatives which are reduced under regioselective cond

2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS

The invention relates to 2-thio-substituted imidazole derivatives of formula (I), wherein the radicals R1, R2, R3 and m have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an action that inhibits the release of cytokines and are thus suited for treating diseases associated with a disorder of the immune system.

Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes

A series of polysubstituted pyridin-4-yl imidazole inhibitors of p38 MAP (mitogen-activated protein) kinase was prepared as small molecular anticytokine agents and drug candidates for the treatment of chronic inflammatory diseases. The contribution of sub