94494-35-6

Basic information

• Product Name: 2(1H)-Pyrazinone, 4-(cyclohexylcarbonyl)-3,4-dihydro-1-(2-phenylethyl)-
• CAS NO: 94494-35-6
• Molecular Formula: C19H24N2O2
• Molecular Weight: 312.412
• Mol File: 94494-35-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2(1H)-Pyrazinone, 4-(cyclohexylcarbonyl)-3,4-dihydro-1-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrazinone, 4-(cyclohexylcarbonyl)-3,4-dihydro-1-(2-phenylethyl)-(94494-35-6)
• EPA Substance Registry System: 2(1H)-Pyrazinone, 4-(cyclohexylcarbonyl)-3,4-dihydro-1-(2-phenylethyl)-(94494-35-6)

Safety Data

• Hazardous Substances Data: 94494-35-6(Hazardous Substances Data)

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 32377-88-1 (cyclohexanecarbonyl-amino)-acetic acid 
• 1372607-34-5 1-cyclohexanecarbonyl-3-methoxy-1,2-dihydropyrazine 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 1074-16-4 2-bromophenylethyl alcohol 
• 406954-89-0 1-[2-(2-bromophenyl)ethyl]-4-(cyclohexylcarbonyl)-1,3,4-trihydropyrazin-2-one 
• 171734-72-8 toluene-4-sulfonic acid 2-(2-bromophenyl)ethyl ester 
• 94508-09-5 N-(2-phenylethyl)aminoacetaldehyde diethyl acetal 
• 13156-95-1 2-chloro-N-phenethylacetamide 
• 64-04-0 phenethylamine 
• 87693-75-2 4-(cyclohexylcarbonyl)-6-hydroxy-1-phenethylpiperazine-2-one 
• 3591-82-0 2-phenylethylaminoacetonitrile 
• 90142-14-6 N-2-phenylethyl 2-N-(2,2-dimethoxyethylamino)acetamide hydrochloride 
• 90142-13-5 N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-phenethylamino)-ethyl)cyclohexanecarboxamide 

Downstream Products

• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 

Relevant articles and documents

One-pot synthesis method of praziquantel intermediate

The invention discloses a one-pot synthesis method of a praziquantel intermediate. The method comprises the steps of adding N-phenylethyl aminoacetaldehyde dialkyl alcohol (A1) and N-cyclohexylformyl glycine (A2) into a reaction vessel, reacting to obtain a compound as shown in a general formula A3, adding a condensation receiving device on the reaction vessel, replacing air in the reaction container and the condensation receiving device with nitrogen, carrying out microwave reaction in a microwave reactor, and after the microwave reaction is finished, adding an organic solvent to crystallize to obtain white solid 4-(cyclohexylcarbonyl)-3, 4-dihydro-1-(2-phenethyl)-2-(1h)-pyrazinone (A4). By adopting the method, the high-purity praziquantel intermediate can be prepared, and the industrial production requirement of the praziquantel intermediate can be met.

A concise and highly efficient synthesis of praziquantel as an anthelmintic drug

A concise and practical synthesis of praziquantel as anthelmintic drug is described. The key steps include a monoalkylation of ethanolamine for the preparation of 2-(2-hydroxyethylamino)-N-phenethylacetamide and a mild oxidation protocol with SO3-Py/DMSO as oxidant to transform alcohol into the corresponding aza-acetal. The telescoped synthesis is composed of five steps without purification of the intermediates, providing an overall yield of 80% with 99.8% purity after crystallization.

A NEW SYNTHESIS 2-ACYL-1,2,3,6,7,11b-HEXAHYDROPYRAZINOISOQUINOLIN-4-ONES BASED ON N-CYANOMETHYL DERIVATIVES OF 2-PHENYL-ETHYLAMIDES OF ACYLGLYCINES

A new route for the synthesis of 2-acyl-1,2,3,6,7,11b-hexahydropyrazinoisoquinolin-4-ones has been studied which includes a stage in which substituted piperazinones are obtained by reductive cyclization of N-cyanomethyl derivatives of 2-phenylethylamides of acylglycines under influence of Raney alloy in formic acid.