944994-03-0Relevant articles and documents
AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR
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Paragraph 0152, (2021/05/29)
A series of pyrazolopymidine derivatives, and use thereof in the preparation of a medicament for treating disease associated with FGFR and c-Met. The pyrazolopymidine derivative is a compound represented by formula (I), a tautomer, or a pharmaceutically acceptable salt thereof.
SUBSTITUTED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS
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Page/Page column 329; 330; 331, (2020/08/28)
Disclosed are compounds of Formula (I) or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor
Chan, Bryan K.,Hanan, Emily J.,Bowman, Krista K.,Bryan, Marian C.,Burdick, Daniel,Chan, Emily,Chen, Yuan,Clausen, Saundra,Dela Vega, Trisha,Dotson, Jennafer,Eigenbrot, Charles,Elliott, Richard L.,Heald, Robert A.,Jackson, Philip S.,Knight, Jamie D.,La, Hank,Lainchbury, Michael D.,Malek, Shiva,Purkey, Hans E.,Schaefer, Gabriele,Schmidt, Stephen,Seward, Eileen M.,Sideris, Steve,Shao, Lily,Wang, Shumei,Yeap, Siew Kuen,Yen, Ivana,Yu, Christine,Heffron, Timothy P.
supporting information, p. 9080 - 9093 (2016/10/22)
Inhibitors targeting the activating mutants of the epidermal growth factor receptor (EGFR) have found success in the treatment of EGFR mutant positive non-small-cell lung cancer. A secondary point mutation (T790M) in the inhibitor binding site has been li
PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS
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Page/Page column 137, (2010/01/12)
Provided are compounds according to Formula (I), or stereoisomer, prodrug, polymorph, or pharmaceutically acceptable salt forms thereof, wherein X, Y, R1, R6 , R7, and R8 are as defined, which compounds are effective inhibitors of PI3-kinase and/or other medically and clinically relevant kinases. Also provided are pharmaceutical compositions and methods of using the compounds and compositions as PB -kinase and kinase inhibitors. More particularly, the compounds of the invention provide treatments and therapeutics for human diseases regulated by, or associated with, the activity of, PI3-kinases and/or protein kinases, or mutant or variant forms thereof.
THIAZOLE DERIVATIVES AND USE THEREOF
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Page/Page column 48, (2008/06/13)
The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infect