945-76-6

Upstream product

• 10557-74-1 3-bromo-5-phenylisoxazole 
• 64-17-5 ethanol 
• 146464-48-4 ethyl formhydroximate 
• 536-74-3 phenylacetylene 
• 300543-25-3 3-ethoxy-5-hydroxy-5-phenyl-4,5-dihydroisoxazole 
• 6738-06-3 phenylethynylmagnesium bromide 
• 110921-61-4 O-ethyl 3-hydroxy-3-phenyl-2-propenethioate 
• 6455-30-7 3-nitro-5-phenylisoxazole 
• 106299-10-9 3,3-diethoxy-1-phenyl-propenone 

Relevant academic research and scientific papers

Synthesis of 3-ethoxyisoxazole derivatives and 3-ethoxy-1H-pyrazole derivatives from β-oxo thionoesters

3-Ethoxyisoxazoles and 3-ethoxy-1H-pyrazoles were obtained in high yields from β-oxo thionoesters. The reaction of the ethyl β-oxo thionoesters with hydroxylamine hydrochloride in the presence of triethylamine at room temperature for 2 h gave the ethyl 3-oxopropiohydroximates and their hemiacetals, which were easily converted to the 3-ethoxyisoxazoles by refluxing for 3 h at pH 3-5. On the other hand, the reaction of the ethyl β-oxo thionoesters with hydrazine derivatives in the presence of triethylamine for 3-8 h at room temperature directly yielded the 3-ethoxy-1H-pyrazoles.

Cycloadditions with Alkoxynitrile Oxides, RO-CN+-O-, (Alkyl Cyanate N-Oxides)

Alkyl formhydroximates have been synthesized by reacting alkyl orthoesters with hydrogen sulfide followed by treatment of the alkyl thioformate formed with hydroxylamine.Chlorination of alkyl formhydroximates with N-chlorosuccinimide gives alkyl chlorofor