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Usage

Uses

Used in Pharmaceutical Industry:
2-Propoxyquinoline is used as a chemical intermediate for the synthesis of pharmaceuticals, particularly for the production of antimalarial drugs such as chloroquine. Its role in drug synthesis is crucial for developing effective treatments against malaria.
Used in Agrochemical Industry:
2-Propoxyquinoline is utilized as a precursor in the development of agrochemicals, contributing to the creation of products that protect crops and enhance agricultural productivity.
Used in Antioxidant Applications:
2-Propoxyquinoline is employed as an antioxidant, protecting cells from oxidative stress and potentially reducing the risk of various diseases associated with oxidative damage.
Used in Neurological Disorder Treatment:
2-Propoxyquinoline is studied for its potential use in the treatment of neurological disorders, due to its ability to modulate cellular processes and protect neurons from damage.
Used in Cancer Therapy:
2-Propoxyquinoline is investigated for its potential role in cancer treatment, as it may exhibit anticancer properties and contribute to the development of novel therapeutic strategies.
Used in Antimicrobial Applications:
2-Propoxyquinoline is studied for its antibacterial and antifungal activities, indicating its potential use in the development of antimicrobial agents to combat infections caused by various pathogens.

Upstream product

• 612-62-4 2-Chloroquinoline 
• 6819-41-6 sodium n-propoxide 
• 71-23-8 propan-1-ol 
• 1613-37-2 Quinoline N-oxide 

Relevant academic research and scientific papers

A Direct C2-Selective Phenoxylation and Alkoxylation of Quinoline N-Oxides with Various Phenols and Alcohols in the Presence of H-Phosphonate

A practical and efficient method for the synthesis of 2-aroxy(alkoxy)quinolines has been developed by direct cross-dehydrogenative coupling reaction between quinoline N-oxides and readily available phenols and alcohols in the presence of H-phosphonate and

Synthesis and molecular modeling study of new trimeric quinoline derivatives

Di- and trimeric quinoline derivatives have been recently described as potential modulators of Bcl-2 family protein interactions. However, only a few trimeric compounds have been described so far and an enlargement of the number of analogs of this class is needed to expand the structure-activity relationship study. Therefore, the synthesis of six new trimeric quinoline derivatives is reported. Moreover molecular modeling experiments were performed to study the conformational arrangement of compound 36 in Bak binding site of Bcl-x L, showing that these compounds could be potential ligands for Bcl-xL.

DEOXYGENATIVE 2-ALKOXYLATION OF QUINOLINE 1-OXIDE

Treatment of quinoline 1-oxide (1) with ethyl chloroformate or tosyl chloride and triethylamine in some lower alcohols affords the corresponding 2-alkoxyquinolines (2a-f) in generally satisfactory yields.Reactions of 2-methylpyridine and 2-methylquinoline 1-oxides lead to the corresponding 2-ethoxycarbonyloxymethyl (3 and 5) and 2-ethoxymethyl derivatives (4 and 6).