94501-15-2Relevant academic research and scientific papers
Synthesis of Vinyl Carboxylic Acids using Carbon Dioxide as a Carbon Source by Iron-Catalyzed Hydromagnesiation
Santhoshkumar, Rajagopal,Hong, Ya-Chun,Luo, Ching-Zong,Wu, Yun-Ching,Hung, Chen-Hsun,Hwang, Kuen-Yuan,Tu, An-Pang,Cheng, Chien-Hong
, p. 2210 - 2213 (2016/07/19)
An iron-catalyzed synthesis of α,β-unsaturated carboxylic acids from alkynes and carbon dioxide was developed. This reaction proceeds through hydromagnesiation of alkynes followed by carbon dioxide insertion under atmospheric pressure and ambient temperature in the presence of iron and a Grignard reagent as a catalyst and hydride source, respectively. Several symmetrical and unsymmetrical alkynes were transformed into the corresponding acids in good to excellent yields. The methodology provides an efficient route to the synthesis of vinyl carboxylic acids.
GUANIDINE DERIVATIVES AS TRPC MODULATORS
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Page/Page column 42-43, (2014/02/16)
The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))
