945031-66-3Relevant academic research and scientific papers
Cyclic disulfides as functional mimics of the histone deacetylase inhibitor FK-228
Mays, Jared R.,Restituyo, José A.,Katzenberger, Rebeccah J.,Wassarman, David A.,Rajski, Scott R.
, p. 4579 - 4583 (2007)
FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition.
FK228 analogs and methods of making and using the same
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Page/Page column 23; 24; sheet 6, (2010/11/08)
The present invention provides FK228 analogs and methods of making and using the same. Such analogs are potent inhibitors of histone deacetylase and, in certain embodiments, are capable of specifically targeting cancerous cells and tissues. In preferred e
