Cyclic disulfides as functional mimics of the histone deacetylase inhibitor FK-228

DOI: 10.1016/j.tetlet.2007.04.123

Source and publish data:

Tetrahedron Letters p. 4579 - 4583 (2007)

Update date:2022-08-02

Topics:

Authors:

Mays, Jared R.

Restituyo, José A.

Katzenberger, Rebeccah J.

Wassarman, David A.

Rajski, Scott R.

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Article abstract of DOI:10.1016/j.tetlet.2007.04.123

FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition.

Full text of DOI:10.1016/j.tetlet.2007.04.123

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