945034-24-2Relevant academic research and scientific papers
Isocombretastatins A: 1,1-Diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds
Alvarez, Raquel,Alvarez, Concepcion,Mollinedo, Faustino,Sierra, Beatriz G.,Medarde, Manuel,Pelaez, Rafael
scheme or table, p. 6422 - 6431 (2011/02/24)
Isocombretastatins A are 1,1-diarylethene isomers of combretastatins A. We have synthesized the isomers of combretastatin A-4, deoxycombretastatin A-4, 3-amino-deoxycombretastatin A-4 (AVE-8063), naphthylcombretastatin and the N-methyl- and N-ethyl-5-indo
Naphthylphenstatins as tubulin ligands: Synthesis and biological evaluation
Alvarez, Concepcion,Alvarez, Raquel,Corchete, Purificacion,Perez-Melero, Concepcion,Pelaez, Rafael,Medarde, Manuel
experimental part, p. 8999 - 9008 (2009/04/11)
A new family of naphthalenic analogues of phenstatins with modifications on the ketone-bridge has been synthesised. The synthesised compounds have been assayed for tubulin polymerisation inhibitory activity as well as for cytotoxic activity against cancer
Synthesis and biological activity of naphthalene analogues of phenstatins: Naphthylphenstatins
Alvarez, Concepcion,Alvarez, Raquel,Corchete, Purificacion,Perez-Melero, Concepcion,Pelaez, Rafael,Medarde, Manuel
, p. 3417 - 3420 (2008/02/09)
Novel phenstatin analogues with a 2-naphthyl moiety combined with either a 2,3,4- or a 3,4,5-trimethoxyphenyl ring have been synthesized, and their tubulin polymerization inhibiting and cytotoxic activities have been evaluated. The 2-naphthyl ring is a be
