945040-37-9Relevant academic research and scientific papers
Synthesis and anti-tumor activities of a novel series of tricyclic 1-anilino-5H-pyridazino[4,5-b]indoles
Rong, Dong Li,Zhai, Xin,Yan, Fang Zhao,Yu, Shuang,Gong, Ping
, p. 424 - 428 (2008/12/21)
A novel series of 1-anilino-5H-pyridazino[4,5-b]indoles was designed and synthesized in order to find novel potent anti-tumor compounds. Their structures were confirmed by MS, 1H-NMR, and elemental analysis. All compounds were screened for their cytotoxic activity against two human cancer cell lines (Bel-7420, HT-1080). The compounds 8, 9, and 17 showed 50% growth inhibitory activity in low micromolar concentration (IC50 = 7.7～12.8 μM). Among them, compound 17 displayed the most potent anti-tumor activity with IC50 values of 8.2 μM and 7.9 μM against Bel-7402 and HT-1080, respectively.
