Cas 945041-33-8,7-bromo-1-(4-trifluoromethylphenylamino)-5-cyclopropyl-8-[3-(pyrrolidin-1-yl)propoxy]-5H-pyridazino[4,5-b]indole

945041-33-8

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Basic information

Product Name: 7-bromo-1-(4-trifluoromethylphenylamino)-5-cyclopropyl-8-[3-(pyrrolidin-1-yl)propoxy]-5H-pyridazino[4,5-b]indole
Synonyms: 7-bromo-1-(4-trifluoromethylphenylamino)-5-cyclopropyl-8-[3-(pyrrolidin-1-yl)propoxy]-5H-pyridazino[4,5-b]indole
CAS NO:945041-33-8
Molecular Formula:
Molecular Weight: 574.443
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 7-bromo-1-(4-trifluoromethylphenylamino)-5-cyclopropyl-8-[3-(pyrrolidin-1-yl)propoxy]-5H-pyridazino[4,5-b]indole(CAS DataBase Reference)
NIST Chemistry Reference: 7-bromo-1-(4-trifluoromethylphenylamino)-5-cyclopropyl-8-[3-(pyrrolidin-1-yl)propoxy]-5H-pyridazino[4,5-b]indole(945041-33-8)
EPA Substance Registry System: 7-bromo-1-(4-trifluoromethylphenylamino)-5-cyclopropyl-8-[3-(pyrrolidin-1-yl)propoxy]-5H-pyridazino[4,5-b]indole(945041-33-8)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 945041-33-8(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 945041-33-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,5,0,4 and 1 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 945041-33:
(8*9)+(7*4)+(6*5)+(5*0)+(4*4)+(3*1)+(2*3)+(1*3)=158
158 % 10 = 8
So 945041-33-8 is a valid CAS Registry Number.

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945041-33-8Relevant academic research and scientific papers

Synthesis and anti-tumor activities of a novel series of tricyclic 1-anilino-5H-pyridazino[4,5-b]indoles

Rong, Dong Li,Zhai, Xin,Yan, Fang Zhao,Yu, Shuang,Gong, Ping

, p. 424 - 428 (2008/12/21)

A novel series of 1-anilino-5H-pyridazino[4,5-b]indoles was designed and synthesized in order to find novel potent anti-tumor compounds. Their structures were confirmed by MS, 1H-NMR, and elemental analysis. All compounds were screened for their cytotoxic activity against two human cancer cell lines (Bel-7420, HT-1080). The compounds 8, 9, and 17 showed 50% growth inhibitory activity in low micromolar concentration (IC50 = 7.7～12.8 μM). Among them, compound 17 displayed the most potent anti-tumor activity with IC50 values of 8.2 μM and 7.9 μM against Bel-7402 and HT-1080, respectively.

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