94514-48-4Relevant academic research and scientific papers
BENZISOTHIAZOL-3(1H)-ONE-5-SULFONYL DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS
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Paragraph 0260; 0261; 0262, (2013/06/27)
The present invention relates to novel benzisothiazol-3(1H)-one-5-sulfonyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
Synthesis of nitropolychlorinated dibenzo-p-dioxins (NPCDDs) and their photochemical reaction with nucleophiles
Merica, Simona G.,Bunce, Nigel J.
, p. 826 - 834 (2007/10/03)
A series nitropolychlorodibenzo-p-dioxins (NPCDDs) was synthesized by condensation between catechols and 2,6-dinitrochalobenzene derivatives.In the presence of sodium ethoxide in anhydrous ethanol, these underwent photochemical SN2Ar* substitutions meta to the nitro group in high chemical yield and moderate quantum yield.Both ring-opening and chloride replacement reactions were observed.The reactions involved the triplet excited state of the NPCDD, and showed a linear relationship between Φ-1 and -1.Analogous reactions with KCN in methanol showed similar behaviour, but the products could not be isolated.Key words: photosubstitution, SN2Ar*, dibenzo-p-dioxins.
An Improved Synthesis of Substituted Dibenzodioxines
Lee, Ho H.,Denny, William A.
, p. 1071 - 1074 (2007/10/02)
An improved general synthesis of substituted dibenzodioxines by reaction of catechol and substituted 1,2-dichloro- or 2-chloronitro-benzenes with metallic potassium in hexamethylphosphoramide is reported.The yields are generally superior to those in published methods, and in particular the reaction appears the one of choice for the synthesis of both the parent dibenzodioxine and the 1-carboxy derivative.
