945213-34-3Relevant articles and documents
An aminocatalyzed michael addition/Iron-Mediated decarboxylative cyclization sequence for the preparation of 2,3,4,6-Tetrasubstituted pyridines: Scope and mechanistic insights
Stivanin, Mateus L.,Duarte, Marcelo,Sartori, Camila,Capreti, Naylil M.R.,Angolini, Celio F.F.,Jurberg, Igor D.
, p. 10319 - 10330 (2017)
A novel, scalable strategy for the preparation of 2,3,4,6-tetrasubstituted pyridines is described. This protocol has two steps: an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, followed by an iron-mediated decarboxylative cyclization event. Mechanistic insights for both steps are provided based on HRMS-ESI(+) studies.
Iodine-catalyzed aerobic oxidative formal [4+2] annulation for the construction of polyfunctionalized pyridines
Zhu, Chunyin,Bi, Benwei,Ding, Ya,Zhang, Te,Chen, Qiu-Yun
supporting information, p. 9251 - 9257 (2015/11/27)
An iodine-catalyzed aerobic oxidative formal [4+2] annulation for the construction of polyfunctionalized pyridines in one step has been developed through the green reaction system of catalytic amounts of molecular iodine and amine in combination with oxyg
Three-step synthesis of 2,4-diaryl-5,6,7,8-tetrahydroquinoline derivatives
Gezegen, Hayreddin,Dingil, Alparslan,Ceylan, Mustafa
experimental part, p. 1017 - 1024 (2010/10/21)
(Chemical Equation Presented) Addition of cylohexanone to chalcones, obtained from the appropriate acetophenone and benzaldehyde derivatives, under solvent-free conditions gave 1,5-diketones in good yields. Treatment of 1,5-diketones with ammonium acetate in acetic acid afforded directly 2,4-diaryl-5,6,7,8-tetrahydroquinoline derivatives (7a-u) in high yields. The structures of 7a-u were elucidated by 1H NMR, 13C NMR, IR, and elemental analysis.
