945216-88-6Relevant articles and documents
3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists
Zhao, Shu-Hai,Berger, Jacob,Clark, Robin D.,Sethofer, Steven G.,Krauss, Nancy E.,Brothers, Julie M.,Martin, Renee S.,Misner, Dinah L.,Schwab, Dietmar,Alexandrova, Ludmila
, p. 3504 - 3507 (2008/02/09)
A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT6 receptor antagonists. Many of the compounds displayed subnanomolar affinities for the 5-HT6 receptor and good brain penetration in rats. The relationship of structure and lipophilicity to hERG inhibition of this series of compounds is discussed.