343269-51-2Relevant academic research and scientific papers
Preparation method for multisubstituted benzoxazole compound
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Paragraph 0021-0022, (2018/04/02)
The invention discloses a preparation method for a multisubstituted benzoxazole compound namely 2-chloro-7-bromobenzo[d]oxazole-5-formaldehyde. The preparation method prepares a target product with 2-bromo-4-methyl-6-nitrophenol as a starting material thr
3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists
Zhao, Shu-Hai,Berger, Jacob,Clark, Robin D.,Sethofer, Steven G.,Krauss, Nancy E.,Brothers, Julie M.,Martin, Renee S.,Misner, Dinah L.,Schwab, Dietmar,Alexandrova, Ludmila
, p. 3504 - 3507 (2008/02/09)
A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT6 receptor antagonists. Many of the compounds displayed subnanomolar affinities for the 5-HT6 receptor and good brain penetration in rats. The relationship of structure and lipophilicity to hERG inhibition of this series of compounds is discussed.
