945256-00-8

Basic information

• Product Name: N-(1-{3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-5-triisopropylsilanyloxy-1H-indol-2-yl}-ethyl)-2-(2-phenyl-1H-indol-3-yl)-acetamide
• Synonyms: N-(1-{3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-5-triisopropylsilanyloxy-1H-indol-2-yl}-ethyl)-2-(2-phenyl-1H-indol-3-yl)-acetamide
• CAS NO: 945256-00-8
• Molecular Weight: 797.169
• Mol File: 945256-00-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(1-{3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-5-triisopropylsilanyloxy-1H-indol-2-yl}-ethyl)-2-(2-phenyl-1H-indol-3-yl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-{3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-5-triisopropylsilanyloxy-1H-indol-2-yl}-ethyl)-2-(2-phenyl-1H-indol-3-yl)-acetamide(945256-00-8)
• EPA Substance Registry System: N-(1-{3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-5-triisopropylsilanyloxy-1H-indol-2-yl}-ethyl)-2-(2-phenyl-1H-indol-3-yl)-acetamide(945256-00-8)

Safety Data

• Hazardous Substances Data: 945256-00-8(Hazardous Substances Data)

Upstream product

• 140139-82-8 1-(5-Methoxy-3-methyl-1H-indol-2-yl)-ethanone 
• 937177-50-9 2-(1-azido-ethyl)-1-[4-(2-chloro-ethoxy)-benzyl]-3-methyl-5-triisopropylsilanyloxy-1H-indole 
• 937177-49-6 1-{1-[4-(2-chloro-ethoxy)-benzyl]-3-methyl-5-triisopropylsilanyloxy-1H-indol-2-yl}-ethanol 
• 937177-48-5 1-{1-[4-(2-chloro-ethoxy)-benzyl]-3-methyl-5-triisopropylsilanyloxy-1H-indol-2-yl}-ethanone 
• 937177-46-3 1-(5-hydroxy-3-methyl-1H-indol-2-yl)-ethanone 
• 198481-13-9 1-Bromomethyl-4-(2-chloro-ethoxy)-benzene 
• 110-89-4 piperidine 
• 937177-53-2 1-{3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-5-triisopropylsilanyloxy-1H-indol-2-yl}-ethylamine 
• 4662-03-7 2-phenylindole-3-acetic acid 
• 13154-24-0 triisopropylsilyl chloride 
• 945255-86-7 2-(1-azido-ethyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-5-triisopropylsilanyloxy-1H-indole 
• 937177-47-4 1-(3-methyl-5-triisopropylsilanyloxy-1H-indol-2-yl)-ethanone 

Relevant articles and documents

Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERα

A novel class of indole ligands for estrogen receptor α have been discovered which exhibit potent affinity and high selectivity. Substitution of the bazedoxifene skeleton to the linker present in the HTS lead 1a provided 22b which was found to be 130-fold α-selective and acted as an antagonist of estradiol activity in uterine tissue and MCF-7 cancer cells.