4662-03-7

Basic information

• Product Name: (2-PHENYL-1H-INDOL-3-YL)ACETIC ACID
• Synonyms: RARECHEM AL BO 0894;(2-PHENYL-1H-INDOL-3-YL)ACETIC ACID;2-PHENYLINDOLE-3-ACETIC ACID;2-(2-Phenyl-1H-indol-3-yl)acetic acid
• CAS NO: 4662-03-7
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.28
• Mol File: 4662-03-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 174-176 °C
• Boiling Point: 527.0±38.0 °C(Predicted)
• Appearance: /
• Density: 1.291±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.75±0.30(Predicted)
• CAS DataBase Reference: (2-PHENYL-1H-INDOL-3-YL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-PHENYL-1H-INDOL-3-YL)ACETIC ACID(4662-03-7)
• EPA Substance Registry System: (2-PHENYL-1H-INDOL-3-YL)ACETIC ACID(4662-03-7)

Safety Data

• Hazardous Substances Data: 4662-03-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 14, p. 1272, 1966 DOI: 10.1248/cpb.14.1272

Upstream product

• 100-63-0 phenylhydrazine 
• 2051-95-8 succinylbenzene 
• 100-52-7 benzaldehyde 
• 58106-56-2 ethyl (E)-3-(2-aminophenyl)acrylate 
• 87-51-4 indole-3-acetic acid 
• 144930-50-7 mesityl(phenyl)iodonium triflouromethanesulfonate 
• 591-50-4 iodobenzene 
• 27005-52-3 2-(2-phenyl-1H-indol-3-yl)acetonitrile 
• 36779-17-6 methyl 2-phenyl-1H-indole-3-carboxylate 
• 59050-38-3 2-phenyl-indole-3-carboxylic acid 
• 107734-06-5 N-tosyl-2-phenylindole 
• 948-65-2 2-phenyl-indole 
• 105-36-2 ethyl bromoacetate 
• 4567-06-0 (2-phenyl-1H-indol-3-yl)acetic acid ethyl ester 

Downstream Products

• 1278540-60-5 C₃₀H₂₂ClNO₃ 
• 1278540-55-8 C₂₃H₁₆ClNO₃ 
• 1278540-65-0 C₂₃H₁₉NO₂ 
• 147375-18-6 2-(2-phenyl-1H-indol-3-yl)-1-(piperidin-1-yl)ethan-1-one 
• 4567-05-9 (2-phenyl-1H-indol-3-yl)acetic acid methyl ester 
• 945255-99-2 N-[1-(3-methyl-1-{4-[2-(3-methyl-pyrrolidin-1-yl)-ethoxy]-benzyl}-5-triisopropylsilanyloxy-1H-indol-2-yl)-ethyl]-2-(2-phenyl-1H-indol-3-yl)-acetamide 
• 945256-00-8 N-(1-{3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-5-triisopropylsilanyloxy-1H-indol-2-yl}-ethyl)-2-(2-phenyl-1H-indol-3-yl)-acetamide 
• 937177-60-1 N-[3-(4-methoxymethoxy-phenyl)-1-methyl-propyl]-2-(2-phenyl-1H-indol-3-yl)-acetamide 

Relevant articles and documents

HETEROAROMATIC INHIBITORS OF ASTACIN PROTEINASES

The present invention relates to novel hydroxamic acid derivatives useful as inhibitors of astacin metalloproteinases, in particular procollagen C-proteinase (PCP) enzymes, meprins, ovastacin and/or nematode astacins; more particularly human or mammalian

Access to 2-Arylindoles via Decarboxylative C?C Coupling in Aqueous Medium and to Heteroaryl Carboxylates under Base-Free Conditions using Diaryliodonium Salts

Easily accessible heteroaromatic carboxylic acids and diaryliodonium salts were successfully employed to construct valuable 2-arylindoles and heteroaryl carboxylates in a regioselective fashion. C2-arylated indoles were produced using a Pd-catalyzed decarboxylative strategy in water without any base, oxidant, or ligand. Heteroaryl carboxylates were prepared under metal and base-free conditions. This protocol was successfully utilized to synthesize Paullone, a cyclin-dependent kinase (CDK) inhibitor.

Synthesis of C-2 arylated tryptophan amino acids and related compounds through palladium-catalyzed C-H Activation

Tryptophan (Trp) and tryptophan derivatives are C2-arylated. A C-H activation process allows the preparation of both protected and unprotected arylated-Trp amino acids, directly from the amino acid precursor and aryl iodides. The obtained compounds are suitable for standard solid-phase peptide synthesis.