945410-46-8Relevant articles and documents
Organocatalysis in conjugate amine additions. Synthesis of β-amino acid derivatives
Sibi, Mukund P.,Itoh, Kennosuke
, p. 8064 - 8065 (2008/02/09)
Conjugate addition of O-protected hydroxylamines to pyrazole-derived enoates proceeds with high efficiency and enantioselectivity when chiral thioureas are used as activators. A wide variety of substrates undergo conjugate amine addition providing access to enantioenriched β-amino acid derivatives. Structural requirements for the optimal thiourea catalyst have been established, and the results suggest that it operates as a bifunctional catalyst. Copyright