945489-93-0

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl (3-[(2,6-bis(hydroxymethyl)pyridin-4-yl)oxy]propyl)carbamate is used as a pharmaceutical compound for its potential therapeutic effects, leveraging its unique structure to interact with biological targets and pathways.
Used in Agricultural Industry:
In the agricultural sector, tert-butyl (3-[(2,6-bis(hydroxymethyl)pyridin-4-yl)oxy]propyl)carbamate is used as a chemical agent for its possible applications in crop protection or enhancement of plant growth, owing to its ability to bind with biological molecules and influence physiological processes.
Used in Industrial Applications:
Tert-butyl (3-[(2,6-bis(hydroxymethyl)pyridin-4-yl)oxy]propyl)carbamate is utilized in industrial processes as a specialty chemical, potentially serving as a catalyst, intermediate, or additive in the synthesis of other compounds or materials, due to its reactive functional groups and structural features.

Upstream product

• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 

Downstream Products

• 945489-92-9 (4-(3-[(tert-butoxycarbonyl)amino]propoxy)pyridine-2,6-diyl)-bis(methylene)bis(4-methylbenzenesulfonate) 

Relevant academic research and scientific papers

BIFUNCTIONAL PHOSPHONATE CHELATING AGENTS

Compounds of the following Formula (I): in which A represents either a nitrogen atom, or a ring having 3 to 6 carbon atoms, or an aromatic ring having 5 to 10 members, the ring and the aromatic ring optionally include one or more heteroatoms selected from N, O and S, and W represents a grafting function and X and Y represent chelating functions.

Synthesis of an activated phosphonated bifunctional chelate with potential for PET imaging and radiotherapy

The synthesis of a phosphonated acyclic bifunctional chelate L* for the labeling of biomaterial is described. L* is based on a pyridine backbone, functionalized in ortho positions by aminomethyl-bis-methylphosphonic acids, and, in the para position, by a side chain containing a reactive NHS carbamate function. The stability of L* in aqueous solutions at different pH values was studied by mass spectrometry, showing the activated function to be sensitive to hydrolysis above neutral pH. The reactivity of L* towards amine functions was tested using ethylamine under different conditions of pH and concentrations, and by the labeling of two reference peptides containing both an N-terminal amino function and a ε-amino group of a lysine residue in the backbone, and a supplementary thiol group of a cysteine residue for one of these two peptides. The results showed the coupling to be efficient at pH 8.0, with a total selectivity for the terminal amine function with respect to lysine and cysteine. The labeling was further performed on B28-13, a mouse monoclonal antibody specifically recognizing tenascin-C protein in human cancer. The labeled antibody was characterized by means of mass spectrometry and spectrofluorimetry, unraveling a labeling ratio of one chelate per antibody. Finally, the affinity of the labeled antibody towards its target was controlled by immunofluorescence staining experiments on human colon cancer biopsies, confirming the affinity of the labeled peptide for tenascin-C.