94549-77-6Relevant academic research and scientific papers
New, short synthesis of arylnaphthofuranone lignans based on reactions of o-aroylbenzyllithiums with furan-2(5H)-one
Kobayashi, Kazuhiro,Tokimatsu, Junsuke,Maeda, Kouji,Morikawa, Osamu,Konishi, Hasatoshi
, p. 3013 - 3016 (2007/10/03)
A simple and general method to prepare 9-arylnaphthofuran-1(3H)-one derivatives has been developed.The reaction of o-aroylbenzyllithiums with furan-2(5H)-one gave the corresponding adducts 5-8 and 5'-7', which upon treatment with thionyl chloride in pyridine followed by dehydrogenation with Pd-C in refluxing p-cymene afforded the arylnaphthofuranone derivatives 13-16.The process proved to be applicable to the preparation of some 1-aryl type naphthofuranone lignans (collinusin, dehydrodimethylretrodendrin and justicidin B).
