6258-44-2Relevant academic research and scientific papers
New, short synthesis of arylnaphthofuranone lignans based on reactions of o-aroylbenzyllithiums with furan-2(5H)-one
Kobayashi, Kazuhiro,Tokimatsu, Junsuke,Maeda, Kouji,Morikawa, Osamu,Konishi, Hasatoshi
, p. 3013 - 3016 (2007/10/03)
A simple and general method to prepare 9-arylnaphthofuran-1(3H)-one derivatives has been developed.The reaction of o-aroylbenzyllithiums with furan-2(5H)-one gave the corresponding adducts 5-8 and 5'-7', which upon treatment with thionyl chloride in pyridine followed by dehydrogenation with Pd-C in refluxing p-cymene afforded the arylnaphthofuranone derivatives 13-16.The process proved to be applicable to the preparation of some 1-aryl type naphthofuranone lignans (collinusin, dehydrodimethylretrodendrin and justicidin B).
Facila Construction of the 1-Phenylnaphthyl Skeleton via an Ester-mediated Nucleophilic Aromatic Substitution Reaction. Applications to the Synthesis of Phenylnaphthalide Lignans
Hattori, Tetsutaro,Tanaka, Hideyuki,Okaishi, Yoshikazu,Miyano, Sotaro
, p. 235 - 242 (2007/10/02)
A convenient method is presented for the construction of the 1-phenylnaphthyl skeleton via an ester-mediated nucleophilic displacement of a methoxy group from an aromatic nucleus by Grignard nucleophiles.Thus, treatment of isopropyl 1-methoxy-2-naphthoate
Chemistry of Aryloxazolines. Applications to the Synthesis of Lignan Lactone Derivatives
Meyers, A. I.,Avila, Walter B.
, p. 3881 - 3886 (2007/10/02)
The syntheses of several lignan lactone derivatives using aryloxazolines as the pivotal intermediates have been investigated.Metalations on naphthyloxazolines followed by electrophilic addition gave one of the appropriate substituents, whereas methoxy dis
