945495-31-8Relevant academic research and scientific papers
Norcantharidin analogues - Synthesis and evaluation of growth inhibition in a panel of selected tumor-cell lines
Deng, Liping,Shen, Li,Zhang, Jing,Yang, Bo,He, Qiaojun,Hu, Yongzhou
, p. 938 - 944 (2007)
A series of norcantharidin (NCTD) analogues have been synthesized by [3+2]1,3-dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with four nitrile oximes. All analogues have been screened for their antiproliferative activity in vitro against a panel of tumor cell lines: KB, SGC-7901, HL60, Bel-7402, HO-8910, and ECA109, producing IC 50 values from 0.36 μmol/L to >100 μmol/L. Compound 9d showed potency for the treatment of hepatoma, with IC50 value to Bel-7402 cell line comparable to that of norcantharidin.
