945619-19-2Relevant academic research and scientific papers
Allosteric inhibitors of hepatitis C polymerase: Discovery of potent and orally bioavailable carbon-linked dihydropyrones
Li, Hui,Linton, Angelica,Tatlock, John,Gonzalez, Javier,Borchardt, Allen,Abreo, Mel,Jewell, Tanya,Patel, Leena,Drowns, Matthew,Ludlum, Sarah,Goble, Mike,Yang, Michele,Blazel, Julie,Rahavendran, Ravi,Skor, Heather,Shi, Stephanie,Lewis, Cristina,Fuhrman, Sheila
, p. 3969 - 3972 (2008/02/11)
The discovery and optimization of a novel class of carbon-linked dihydropyrones as allosteric HCV NS5B polymerase inhibitors are presented. Replacement of the sulfur linker atom with carbon reduced compound acidity and greatly increased cell permeation. F
